Increasing memory load modulates regional brain activity in older adults as measured by fMRI

Jeffrey R. Petrella, Brent A. Townsend, Amishi Jha, Lauretta A. Ziajko, Melissa J. Slavin, Cindy Lustig, Sarah J. Hart, P. Murali Doraiswamy

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Several recent studies using functional magnetic resonance imaging (fMRI) during recognition memory tests have suggested that the ability to neuromodulate as a function of cognitive demand may be impaired in older adults due to age-related cell loss and neural volume reduction in memory specific regions. In the current study, older adults (ages 59-77) were tested with fMRI during a delayed-recognition task in which memory load for faces was varied across trials. Activity was greater in amplitude for three- versus one-face stimuli within the superior, middle, and inferior frontal gyri, intraparietal sulcus, and fusiform gyrus. It was concluded that the ability to modulate activity with increasing load is preserved in older adults despite reductions in neural volume.

Original languageEnglish
Pages (from-to)75-83
Number of pages9
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume17
Issue number1
DOIs
StatePublished - Dec 1 2005
Externally publishedYes

Fingerprint

Aptitude
Magnetic Resonance Imaging
Prefrontal Cortex
Brain
Parietal Lobe
Temporal Lobe
Cognition
Recognition (Psychology)

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

Increasing memory load modulates regional brain activity in older adults as measured by fMRI. / Petrella, Jeffrey R.; Townsend, Brent A.; Jha, Amishi; Ziajko, Lauretta A.; Slavin, Melissa J.; Lustig, Cindy; Hart, Sarah J.; Doraiswamy, P. Murali.

In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 17, No. 1, 01.12.2005, p. 75-83.

Research output: Contribution to journalArticle

Petrella, Jeffrey R. ; Townsend, Brent A. ; Jha, Amishi ; Ziajko, Lauretta A. ; Slavin, Melissa J. ; Lustig, Cindy ; Hart, Sarah J. ; Doraiswamy, P. Murali. / Increasing memory load modulates regional brain activity in older adults as measured by fMRI. In: Journal of Neuropsychiatry and Clinical Neurosciences. 2005 ; Vol. 17, No. 1. pp. 75-83.
@article{d46cf4de1ca14516b929e4d4c7769145,
title = "Increasing memory load modulates regional brain activity in older adults as measured by fMRI",
abstract = "Several recent studies using functional magnetic resonance imaging (fMRI) during recognition memory tests have suggested that the ability to neuromodulate as a function of cognitive demand may be impaired in older adults due to age-related cell loss and neural volume reduction in memory specific regions. In the current study, older adults (ages 59-77) were tested with fMRI during a delayed-recognition task in which memory load for faces was varied across trials. Activity was greater in amplitude for three- versus one-face stimuli within the superior, middle, and inferior frontal gyri, intraparietal sulcus, and fusiform gyrus. It was concluded that the ability to modulate activity with increasing load is preserved in older adults despite reductions in neural volume.",
author = "Petrella, {Jeffrey R.} and Townsend, {Brent A.} and Amishi Jha and Ziajko, {Lauretta A.} and Slavin, {Melissa J.} and Cindy Lustig and Hart, {Sarah J.} and Doraiswamy, {P. Murali}",
year = "2005",
month = "12",
day = "1",
doi = "10.1176/appi.neuropsych.17.1.75",
language = "English",
volume = "17",
pages = "75--83",
journal = "Journal of Neuropsychiatry and Clinical Neurosciences",
issn = "0895-0172",
publisher = "American Psychiatric Publishing Inc.",
number = "1",

}

TY - JOUR

T1 - Increasing memory load modulates regional brain activity in older adults as measured by fMRI

AU - Petrella, Jeffrey R.

AU - Townsend, Brent A.

AU - Jha, Amishi

AU - Ziajko, Lauretta A.

AU - Slavin, Melissa J.

AU - Lustig, Cindy

AU - Hart, Sarah J.

AU - Doraiswamy, P. Murali

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Several recent studies using functional magnetic resonance imaging (fMRI) during recognition memory tests have suggested that the ability to neuromodulate as a function of cognitive demand may be impaired in older adults due to age-related cell loss and neural volume reduction in memory specific regions. In the current study, older adults (ages 59-77) were tested with fMRI during a delayed-recognition task in which memory load for faces was varied across trials. Activity was greater in amplitude for three- versus one-face stimuli within the superior, middle, and inferior frontal gyri, intraparietal sulcus, and fusiform gyrus. It was concluded that the ability to modulate activity with increasing load is preserved in older adults despite reductions in neural volume.

AB - Several recent studies using functional magnetic resonance imaging (fMRI) during recognition memory tests have suggested that the ability to neuromodulate as a function of cognitive demand may be impaired in older adults due to age-related cell loss and neural volume reduction in memory specific regions. In the current study, older adults (ages 59-77) were tested with fMRI during a delayed-recognition task in which memory load for faces was varied across trials. Activity was greater in amplitude for three- versus one-face stimuli within the superior, middle, and inferior frontal gyri, intraparietal sulcus, and fusiform gyrus. It was concluded that the ability to modulate activity with increasing load is preserved in older adults despite reductions in neural volume.

UR - http://www.scopus.com/inward/record.url?scp=14144253293&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=14144253293&partnerID=8YFLogxK

U2 - 10.1176/appi.neuropsych.17.1.75

DO - 10.1176/appi.neuropsych.17.1.75

M3 - Article

C2 - 15746486

AN - SCOPUS:14144253293

VL - 17

SP - 75

EP - 83

JO - Journal of Neuropsychiatry and Clinical Neurosciences

JF - Journal of Neuropsychiatry and Clinical Neurosciences

SN - 0895-0172

IS - 1

ER -