Increasing memory load modulates regional brain activity in older adults as measured by fMRI

Jeffrey R. Petrella, Brent A. Townsend, Amishi P. Jha, Lauretta A. Ziajko, Melissa J. Slavin, Cindy Lustig, Sarah J. Hart, P. Murali Doraiswamy

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Several recent studies using functional magnetic resonance imaging (fMRI) during recognition memory tests have suggested that the ability to neuromodulate as a function of cognitive demand may be impaired in older adults due to age-related cell loss and neural volume reduction in memory specific regions. In the current study, older adults (ages 59-77) were tested with fMRI during a delayed-recognition task in which memory load for faces was varied across trials. Activity was greater in amplitude for three- versus one-face stimuli within the superior, middle, and inferior frontal gyri, intraparietal sulcus, and fusiform gyrus. It was concluded that the ability to modulate activity with increasing load is preserved in older adults despite reductions in neural volume.

Original languageEnglish (US)
Pages (from-to)75-83
Number of pages9
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number1
StatePublished - 2005
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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