Increased Thalamic Gamma Band Activity Correlates with Symptom Relief following Deep Brain Stimulation in Humans with Tourette's Syndrome

Nicholas Maling, Rowshanak Hashemiyoon, Kelly D. Foote, Michael S. Okun, Justin C. Sanchez

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Tourette syndrome (TS) is an idiopathic, childhood-onset neuropsychiatric disorder, which is marked by persistent multiple motor and phonic tics. The disorder is highly disruptive and in some cases completely debilitating. For those with severe, treatment-refractory TS, deep brain stimulation (DBS) has emerged as a possible option, although its mechanism of action is not fully understood. We performed a longitudinal study of the effects of DBS on TS symptomatology while concomitantly examining neurophysiological dynamics. We present the first report of the clinical correlation between the presence of gamma band activity and decreased tic severity. Local field potential recordings from five subjects implanted in the centromedian nucleus (CM) of the thalamus revealed a temporal correlation between the power of gamma band activity and the clinical metrics of symptomatology as measured by the Yale Global Tic Severity Scale and the Modified Rush Tic Rating Scale. Additional studies utilizing short-term stimulation also produced increases in gamma power. Our results suggest that modulation of gamma band activity in both long-term and short-term DBS of the CM is a key factor in mitigating the pathophysiology associated with TS.

Original languageEnglish
Article numbere44215
JournalPLoS One
Volume7
Issue number9
DOIs
StatePublished - Sep 6 2012

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Tics
Tourette Syndrome
Deep Brain Stimulation
signs and symptoms (animals and humans)
Brain
Intralaminar Thalamic Nuclei
brain
rating scales
thalamus
longitudinal studies
pathophysiology
childhood
Refractory materials
mechanism of action
Thalamus
Modulation
Longitudinal Studies
Power (Psychology)
Therapeutics

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Increased Thalamic Gamma Band Activity Correlates with Symptom Relief following Deep Brain Stimulation in Humans with Tourette's Syndrome. / Maling, Nicholas; Hashemiyoon, Rowshanak; Foote, Kelly D.; Okun, Michael S.; Sanchez, Justin C.

In: PLoS One, Vol. 7, No. 9, e44215, 06.09.2012.

Research output: Contribution to journalArticle

Maling, Nicholas ; Hashemiyoon, Rowshanak ; Foote, Kelly D. ; Okun, Michael S. ; Sanchez, Justin C. / Increased Thalamic Gamma Band Activity Correlates with Symptom Relief following Deep Brain Stimulation in Humans with Tourette's Syndrome. In: PLoS One. 2012 ; Vol. 7, No. 9.
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