Increased spinal c-Fos expression with noxious and non-noxious peripheral stimulation after severe spinal contusion

Y. A. Berrocal, D. D. Pearse, C. M. Andrade, J. F. Hechtman, R. Puentes, M. J. Eaton

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The effects of severe contusive spinal cord injury (SCI), at thoracic level 8 (T8), on lumbar c-Fos expression in the spinal cord was investigated. As hypothesized, chronic SCI has a significant effect on expression of c-Fos in the dorsal spinal sensory areas with noxious and innocuous peripheral stimulation of the sciatic nerve. This alteration to stimulation effects was measured using counts of c-Fos immunoreactive cells in the dorsal horn of the L5 lumbar spinal cord in injured animals at 90 days post-injury and in uninjured controls. The number of c-Fos immunoreactive cells increased in SCI rats only after noxious peripheral stimulation (electrical and chemical) suggesting a general increase in excitability in spinal pathways (central sensitization) associated with chronic SCI. These altered responses may represent a functional anatomical reorganization of spinal cord circuitry leading to increased dorsal horn c-Fos expression as a response to severe chronic contusive damage to the spinal cord sensory pathways.

Original languageEnglish (US)
Pages (from-to)58-62
Number of pages5
JournalNeuroscience Letters
Volume413
Issue number1
DOIs
StatePublished - Feb 8 2007

Keywords

  • c-Fos
  • Contusion
  • Dorsal horn
  • Neuropathic pain
  • Non-noxious stimulation
  • Noxious stimulation
  • SCI

ASJC Scopus subject areas

  • Neuroscience(all)

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