Increased serum copper in primary pulmonary hypertension: A possible pathogenic link?

T. Ahmed, M. A. Sackner

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In conscious sleep, we showed that intravenous infusion of copper sulfate produced a marked increase in pulmonary vascular resistance which was prevented by alpha-adrenergic blockade or catecholamine depletion. Because of these observations, we measured serum copper in 7 patients with primary pulmonary hypertension, and in 6 normal women. The 5 female patients had taken contraceptive and appetite-suppressant medication in the past. The mean serum copper level was significantly higher in patients with pulmonary hypertension, indicating that increased serum copper may be a cause or a marker of this entity.

Original languageEnglish
Pages (from-to)243-246
Number of pages4
JournalRespiration
Volume47
Issue number4
StatePublished - Jan 1 1985
Externally publishedYes

Fingerprint

Copper
Serum
Copper Sulfate
Appetite Depressants
Contraceptive Agents
Pulmonary Hypertension
Intravenous Infusions
Vascular Resistance
Adrenergic Agents
Catecholamines
Sleep
Familial Primary Pulmonary Hypertension

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Increased serum copper in primary pulmonary hypertension : A possible pathogenic link? / Ahmed, T.; Sackner, M. A.

In: Respiration, Vol. 47, No. 4, 01.01.1985, p. 243-246.

Research output: Contribution to journalArticle

Ahmed, T. ; Sackner, M. A. / Increased serum copper in primary pulmonary hypertension : A possible pathogenic link?. In: Respiration. 1985 ; Vol. 47, No. 4. pp. 243-246.
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