Increased serum copper in primary pulmonary hypertension: A possible pathogenic link?

T. Ahmed, M. A. Sackner

Research output: Contribution to journalArticle

15 Scopus citations


In conscious sleep, we showed that intravenous infusion of copper sulfate produced a marked increase in pulmonary vascular resistance which was prevented by alpha-adrenergic blockade or catecholamine depletion. Because of these observations, we measured serum copper in 7 patients with primary pulmonary hypertension, and in 6 normal women. The 5 female patients had taken contraceptive and appetite-suppressant medication in the past. The mean serum copper level was significantly higher in patients with pulmonary hypertension, indicating that increased serum copper may be a cause or a marker of this entity.

Original languageEnglish
Pages (from-to)243-246
Number of pages4
Issue number4
StatePublished - Jan 1 1985
Externally publishedYes


ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

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