Increased seroreactivity to human T cell lymphoma/leukemia virus-related endogenous sequence-1 gag peptides in patients with human T cell lymphoma/leukemia virus myelopathy

Raisa Perzova, Elliot Graziano, Swathi Sanghi, Caitlin Welch, Patricia Benz, Lynn Abbott, Danielle Lalone, Jordan Glaser, Thomas Loughran, William Sheremata, Bernard J. Poiesz

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2 Scopus citations

Abstract

Previously, we had shown that although only 8% of patients with large granular lymphocytic leukemia (LGLL) were infected with human T cell lymphoma/leukemia virus (HTLV)-2, almost half had antibodies to HTLV Gag and Env peptides. Herein, we investigated whether this could be due to cross-reactive antibodies to two homologous peptides in the Gag protein of the endogenous retrovirus HTLV-related endogenous sequence-1 (HRES-1). In addition, we had previously shown that patients with HTLV neurodegenerative diseases had increased seroreactivity to homologous HERV-K10 endogenous retrovirus peptides. Hence, in this study we also examined whether these patients had increased seroreactivity to the aforementioned HRES-1 Gag peptides. Sera from 100 volunteer blood donors (VBD), 53 patients with LGLL, 74 subjects with HTLV-1 or 2 infection (58 nonmyelopathy and 16 myelopathy), and 83 patients with multiple sclerosis (MS) were evaluated. The HTLV-positive myelopathy (HAM) patients had a statistically increased prevalence of antibodies to both HRES-1 Gag peptides (81%) vs. the VBD (0%), LGLL patients (13%), and MS patients (1%), and the HTLV-positive nonmyelopathy subjects (21%). The data suggest that cross-reactivity to HRES-1 peptides could be involved in the pathogenesis of HAM. The difference between the VBD and LGLL patients was also statistically significant, also suggesting a possible association in a minority of patients.

Original languageEnglish
Pages (from-to)242-249
Number of pages8
JournalAIDS Research and Human Retroviruses
Volume31
Issue number2
DOIs
StatePublished - Feb 1 2015

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ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Perzova, R., Graziano, E., Sanghi, S., Welch, C., Benz, P., Abbott, L., Lalone, D., Glaser, J., Loughran, T., Sheremata, W., & Poiesz, B. J. (2015). Increased seroreactivity to human T cell lymphoma/leukemia virus-related endogenous sequence-1 gag peptides in patients with human T cell lymphoma/leukemia virus myelopathy. AIDS Research and Human Retroviruses, 31(2), 242-249. https://doi.org/10.1089/aid.2014.0171