It has previously been reported that lymphocytes from patients with primary open angle glaucoma and glucocorticoid induced ocular hypertension demonstrate an increased sensitivity to glucocorticoids in vitro. Using the same in vitro assay authors studied the response of the lymphocyte to theophylline. When compared to nonglaucomatous control subjects, the lymphocytes from patients with primary open angle glaucoma and glucocorticoid induced ocular hypertension demonstrated an increased sensitivity to theophylline (p 0.001). )-)?). The concentration of theophylline necessary to inhibit by 50 per cent the uptake of tritiated thymidine into DNA correlated closely with values obtained for prednisolone 21 phosphate (r = +0.748). The possibility that the increased glucocorticoid sensitivity present in lymphocytes may be mediated by cyclic AMP is discussed.
|Original language||English (US)|
|Number of pages||5|
|State||Published - Dec 1 1973|
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