Increased risk of asthma and atopic dermatitis in perinatally HIV-infected children and adolescents

George K. Siberry, Erin Leister, Denise L. Jacobson, Samuel B. Foster, George R. Seage, Steven E Lipshultz, Mary E. Paul, Murli Purswani, Andrew Colin, Gwendolyn B Scott, William T. Shearer

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The incidence of asthma and atopic dermatitis (AD) was evaluated in HIV-infected (n = 451) compared to HIV-exposed (n = 227) but uninfected (HEU) children and adolescents by abstraction from clinical charts. Asthma was more common in HIV-infected compared to HEU children by clinical diagnosis (25% vs. 20%, p = 0.101), by asthma medication use, (31% vs. 22%, p = 0.012), and by clinical diagnosis and/or medication use, (34% vs. 25%, p = 0.012). HIV-infected children had a greater risk of asthma compared to HEU children (HR = 1.37, 95% CI: 1.01 to 1.86). AD was more common in HIV-infected than HEU children (20% vs. 12%, p = 0.009)) and children with AD were more likely to have asthma in both cohorts (41% vs. 29%, p = 0.010). HIV-infected children and adolescents in this study had an increased incidence of asthma and AD, a finding critical for millions of HIV-infected children worldwide.

Original languageEnglish
Pages (from-to)201-208
Number of pages8
JournalClinical Immunology
Volume142
Issue number2
DOIs
StatePublished - Feb 1 2012

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Atopic Dermatitis
Asthma
HIV
Incidence

Keywords

  • Asthma
  • Atopic dermatitis
  • Inhaled corticosteroids
  • Pediatric HIV infection
  • Protease inhibitors

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Siberry, G. K., Leister, E., Jacobson, D. L., Foster, S. B., Seage, G. R., Lipshultz, S. E., ... Shearer, W. T. (2012). Increased risk of asthma and atopic dermatitis in perinatally HIV-infected children and adolescents. Clinical Immunology, 142(2), 201-208. https://doi.org/10.1016/j.clim.2011.10.005

Increased risk of asthma and atopic dermatitis in perinatally HIV-infected children and adolescents. / Siberry, George K.; Leister, Erin; Jacobson, Denise L.; Foster, Samuel B.; Seage, George R.; Lipshultz, Steven E; Paul, Mary E.; Purswani, Murli; Colin, Andrew; Scott, Gwendolyn B; Shearer, William T.

In: Clinical Immunology, Vol. 142, No. 2, 01.02.2012, p. 201-208.

Research output: Contribution to journalArticle

Siberry, GK, Leister, E, Jacobson, DL, Foster, SB, Seage, GR, Lipshultz, SE, Paul, ME, Purswani, M, Colin, A, Scott, GB & Shearer, WT 2012, 'Increased risk of asthma and atopic dermatitis in perinatally HIV-infected children and adolescents', Clinical Immunology, vol. 142, no. 2, pp. 201-208. https://doi.org/10.1016/j.clim.2011.10.005
Siberry GK, Leister E, Jacobson DL, Foster SB, Seage GR, Lipshultz SE et al. Increased risk of asthma and atopic dermatitis in perinatally HIV-infected children and adolescents. Clinical Immunology. 2012 Feb 1;142(2):201-208. https://doi.org/10.1016/j.clim.2011.10.005
Siberry, George K. ; Leister, Erin ; Jacobson, Denise L. ; Foster, Samuel B. ; Seage, George R. ; Lipshultz, Steven E ; Paul, Mary E. ; Purswani, Murli ; Colin, Andrew ; Scott, Gwendolyn B ; Shearer, William T. / Increased risk of asthma and atopic dermatitis in perinatally HIV-infected children and adolescents. In: Clinical Immunology. 2012 ; Vol. 142, No. 2. pp. 201-208.
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