Increased release of LH after administration of LH-RH to men pretreated with clomiphene

Abba J. Kastin, Andrew V. Schally, Carlos Gual, A. Rees Midgley, M. Clinton Miller, Fernando Flores

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


LH-releasing hormone (LH-RH) was administered to 6 men who had been pretreated with clomiphene citrate (200 mg/day) for 8 or 16 days. The ingestion of clomiphene for 8 days resulted in a significant rise in serum LH and FSH levels which did not further increase to a statistically significant extent after another 8 days. Injection of 0.7 mg of highly purified porcine LH-RH on the 8th or 16th day induced a further significant increase in serum LH (141%) and serum FSH (38%). The response to LH-RH, which reached a peak between 16 and 32 min after iv injection, did not differ significantly between the men taking clomiphene for 8 days and those taking it for 16 days. The results demonstrate that LH-RH can further increase the release of LH in subjects whose LH levels already have been elevated by the ingestion of clomiphene.

Original languageEnglish (US)
Pages (from-to)689-692
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Issue number6
StatePublished - Jan 1 1970
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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