Increased release of kaliuretic peptide during immersion-induced central hypervolemia in cirrhotic humans

David L. Vesely, Richard A Preston, William R. Gower, Shirley Chiou, Murray Epstein

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Kaliuretic peptide is a recently discovered potent stimulator of potassium and water excretion. Its role in modulating renal water handling in cirrhotic patients has not been defined. The responses of circulating kaliuretic peptide and atrial natriuretic factor in 8 cirrhotic subjects to water immersion were significantly greater (p < 0.05) than those of 7 healthy volunteers. With cessation of immersion, atrial natriuretic factor decreased within 30 min to preimmersion values, whereas kaliuretic peptide remained significantly elevated > 1 h, suggesting a slower clearance for kaliuretic peptide. The peak diuretic response to immersion corresponded in a temporal fashion to the peak circulating concentration of kaliuretic peptide, suggesting a possible physiological role of kaliuretic peptide in modulating volume homeostasis in cirrhotic humans.

Original languageEnglish
Pages (from-to)128-137
Number of pages10
JournalAmerican Journal of Nephrology
Volume16
Issue number2
StatePublished - Feb 21 1996

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Immersion
Water
Atrial Natriuretic Factor
Diuretics
Potassium
Homeostasis
atrial natriuretic factor precursor (79-98)
Kidney

Keywords

  • Atrial natriuretic peptide
  • Central hypervolemia
  • Kaliuretic peptide
  • Water immersion

ASJC Scopus subject areas

  • Nephrology

Cite this

Increased release of kaliuretic peptide during immersion-induced central hypervolemia in cirrhotic humans. / Vesely, David L.; Preston, Richard A; Gower, William R.; Chiou, Shirley; Epstein, Murray.

In: American Journal of Nephrology, Vol. 16, No. 2, 21.02.1996, p. 128-137.

Research output: Contribution to journalArticle

Vesely, David L. ; Preston, Richard A ; Gower, William R. ; Chiou, Shirley ; Epstein, Murray. / Increased release of kaliuretic peptide during immersion-induced central hypervolemia in cirrhotic humans. In: American Journal of Nephrology. 1996 ; Vol. 16, No. 2. pp. 128-137.
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