Increased potency of four analogues of LH releasing hormone in man

A. J. Kastin, A. Arimura, D. Gonzalez-Barcena, D. H. Coy, M. C. Miller, N. Nishi, L. Lee, H. Duron-Huerta, D. S. Schalch, A. V. Schally

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13 Scopus citations

Abstract

Four analogues of LH releasing hormone (LH RH) were injected iv. in normal men at a dose of 25 μg: des Gly 10 NH 2 LH RH ethylamide (9 EA LH RH); des Gly 10 NH 2 LH RH propylamide (9 PA LH RH); D Ala 6 LH RH; and D Ala 6, des Gly 10 NH 2 LH RH ethylamide (D Ala 6, 9 EA LH RH). Each peptide tested was found to be more potent than LH RH in releasing LH and, to a lesser extent, FSH. The times of the peak values of LH after the analogues were similar to LH RH (about 20 min). However, LH as well as FSH levels were considerably delayed in returning to baseline after administration of D Ala 6, 9 EA LH RH. The half time disappearances of the 9 EA and 9 PA analogues could be tested and were found to be similar to that of LH RH. The increased potency and prolonged duration of action of D Ala 6, 9 EA LH RH suggest the potential usefulness of this compound in stimulating ovulation and perhaps spermatogenesis.

Original languageEnglish (US)
Pages (from-to)202-206
Number of pages5
JournalInternational Journal of Fertility
Volume19
Issue number4
StatePublished - Dec 1 1974
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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    Kastin, A. J., Arimura, A., Gonzalez-Barcena, D., Coy, D. H., Miller, M. C., Nishi, N., Lee, L., Duron-Huerta, H., Schalch, D. S., & Schally, A. V. (1974). Increased potency of four analogues of LH releasing hormone in man. International Journal of Fertility, 19(4), 202-206.