Background: Atypical lymphocyte populations may be seen in the peritransplant setting. In this case report, we describe an unusually high number of CD5+ B-cells (B1a cells) following transplant. Methods: B1a cells identified during routine follow-up by immunophenotypic analysis in a middle-aged man who had a haploidentical stem cell transplant for acute myeloid leukemia were compared with a reference set of post-transplant samples. Results: Increased but polyclonal B1a cells were identified with 100% donor chimerism. Conclusions: Our case demonstrates that a high absolute number of B1a cells may be seen post-transplant and should not be confused with an atypical CD5 + lymphoproliferative disorder. Furthermore, the population of polyclonal CD5+ B lymphocytes from the patient's donor is prominent 7 months post-transplant. This suggests that the maintenance of CD5+ B1 cells prior to conversion to adult-type CD5- B2 cells is not hindered by the recipient adult stromal environment.
- B1a lymphocytes
- lymphocyte subsets
ASJC Scopus subject areas
- Cell Biology
- Pathology and Forensic Medicine