Increased platelet calcium in thrombosis and related disorders and its correction by nifedipine

Y. S. Ahn, W. Jy, W. J. Harrington, N. Shanbaky, L. F. Fernandez, D. H. Haynes

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Using chlorotetracycline (CTC) as a probe we studied calcium homeostasis of platelets in various disorders. Studied were healthy subjects and patients with disorders where platelets play an important role. These included thromboses, hypertension, diabetes mellitus, vasculitis, immune thrombocytopenia, thrombotic thrombocytopenic purpura, myelofibrosis, hemolytic anemias and uremia. Significant elevation of calcium levels were observed in all of these disorders except uremia. Nifedipine reduced or normalized the increased levels in most patients and its discontinuation resulted in a return of the abnormality. We propose that platelets in thromboses and related disorders are exposed to subcritical concentrations of activating factors, leading to enhanced calcium influx and elevated free cytoplasmic calcium followed by elevated resting dense tubular calcium. Nifedipine appears to protect platelets from these stimuli and coupled with their known action on vessel walls, calcium channel blockers show promise as antiatherogenic as well as antithrombotic agents.

Original languageEnglish (US)
Pages (from-to)135-143
Number of pages9
JournalThrombosis Research
Volume45
Issue number2
DOIs
StatePublished - Jan 15 1987

Keywords

  • artherosclerosis
  • CTC probe
  • platelet
  • platelet calcium
  • thromboses

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

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