Increased metabolism of acetylcholine in brain of cats with Gm1 gangliosidosis

Henry J. Baker, Richards S. Jope

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Acetylcholine metabolism was studied in cats with Gm1 gangliosidosis. Marked increases in acetylcholine synthesis (130% of controls) and K+-stimulated release of ACh (142-165% of controls) were observed in cortical and hippocampal brain slices of diseased cats. Cortical synaptosomes prepared from affected cats had significantly elevated rates of high affinity choline transport (131% of controls). These results indicate that in Gm1 gangliosidosis there is an unique disease-induced activation of cholinergic activity in the nervous system. These changes may result from disease-induced proliferation of fucntional cholinergic nerve endings and/or altered regulation of acetylcholine metabolism.

Original languageEnglish (US)
Pages (from-to)363-365
Number of pages3
JournalBrain Research
Volume343
Issue number2
DOIs
StatePublished - Sep 23 1985
Externally publishedYes

Keywords

  • acetylcholine
  • Gm gangliosidosis

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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