Increased lipid peroxidation and antioxidant activity in methionine- induced hepatitis in rabbits

Michal Toborek, Ewa Kopieczna-Grzebieniak, Marian Drózdz, Marian Wieczorek

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The liver is especially susceptible to the toxic effects of methionine due to its role in sulfur amino acid metabolism. Therefore, the excessive amounts of this amino acid may induce liver damage. To test the mechanisms of methionine-related hepatotoxicity, liver thiobarbituric acid reactive substances (TBARS), and activities of superoxide dismutase, catalase and selenium-dependent glutathione peroxidase were measured in rabbits fed a methionine-enriched diet for 6 or 9 mo. Morphological studies of livers were also made. Feeding rabbits the methionine-enriched diet for 9 mo resulted in a significant increase in liver TBARS levels and antioxidant enzyme activities. Moreover, an inflammatory infiltration of portal triads in the treated rabbits were observed. These results indicate that methionine may induce hepatitis by increasing free radical processes.

Original languageEnglish (US)
Pages (from-to)534-537
Number of pages4
JournalNutrition
Volume12
Issue number7-8
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

Keywords

  • antioxidant enzymes
  • hepatitis
  • lipid peroxidation
  • methionine

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Surgery
  • Medicine (miscellaneous)

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