Increased levels of laminin in ascitic fluid of patients with ovarian cancer

Lowell J. Byers, Janet L. Osborne, Linda F. Carson, Jonathan R. Carter, A. F. Haney, J. Brice Weinberg, Sundaram Ramakrishnan

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Laminin is a component of the extracellular matrix and is associated with tumor cell metastasis. Present studies show that the ovarian cancer cell lines produce significant amounts of laminin (54-140 ng/ml) in culture. Since ovarian cancer is associated with ascites production, laminin levels were then determined in ascites and serum. The results indicate that the ascites from patients with serous adenocarcinoma of the ovary had higher levels of laminin than the normal peritoneal fluid (P < 0.0001). However, the serum levels of laminin did not differ significantly between the control population and ovarian cancer patients.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalCancer Letters
Volume88
Issue number1
DOIs
StatePublished - Jan 6 1995
Externally publishedYes

Fingerprint

Ascitic Fluid
Laminin
Ovarian Neoplasms
Ascites
Serum
Extracellular Matrix
Ovary
Adenocarcinoma
Neoplasm Metastasis
Cell Line
Population
Neoplasms

Keywords

  • Ascites
  • Laminin
  • Metastasis
  • Ovarian carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Molecular Biology

Cite this

Byers, L. J., Osborne, J. L., Carson, L. F., Carter, J. R., Haney, A. F., Weinberg, J. B., & Ramakrishnan, S. (1995). Increased levels of laminin in ascitic fluid of patients with ovarian cancer. Cancer Letters, 88(1), 67-72. https://doi.org/10.1016/0304-3835(94)03625-S

Increased levels of laminin in ascitic fluid of patients with ovarian cancer. / Byers, Lowell J.; Osborne, Janet L.; Carson, Linda F.; Carter, Jonathan R.; Haney, A. F.; Weinberg, J. Brice; Ramakrishnan, Sundaram.

In: Cancer Letters, Vol. 88, No. 1, 06.01.1995, p. 67-72.

Research output: Contribution to journalArticle

Byers, LJ, Osborne, JL, Carson, LF, Carter, JR, Haney, AF, Weinberg, JB & Ramakrishnan, S 1995, 'Increased levels of laminin in ascitic fluid of patients with ovarian cancer', Cancer Letters, vol. 88, no. 1, pp. 67-72. https://doi.org/10.1016/0304-3835(94)03625-S
Byers LJ, Osborne JL, Carson LF, Carter JR, Haney AF, Weinberg JB et al. Increased levels of laminin in ascitic fluid of patients with ovarian cancer. Cancer Letters. 1995 Jan 6;88(1):67-72. https://doi.org/10.1016/0304-3835(94)03625-S
Byers, Lowell J. ; Osborne, Janet L. ; Carson, Linda F. ; Carter, Jonathan R. ; Haney, A. F. ; Weinberg, J. Brice ; Ramakrishnan, Sundaram. / Increased levels of laminin in ascitic fluid of patients with ovarian cancer. In: Cancer Letters. 1995 ; Vol. 88, No. 1. pp. 67-72.
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