Increased levels of laminin in ascitic fluid of patients with ovarian cancer

Lowell J. Byers, Janet L. Osborne, Linda F. Carson, Jonathan R. Carter, A. F. Haney, J. Brice Weinberg, Sundaram Ramakrishnan

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Laminin is a component of the extracellular matrix and is associated with tumor cell metastasis. Present studies show that the ovarian cancer cell lines produce significant amounts of laminin (54-140 ng/ml) in culture. Since ovarian cancer is associated with ascites production, laminin levels were then determined in ascites and serum. The results indicate that the ascites from patients with serous adenocarcinoma of the ovary had higher levels of laminin than the normal peritoneal fluid (P < 0.0001). However, the serum levels of laminin did not differ significantly between the control population and ovarian cancer patients.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalCancer letters
Volume88
Issue number1
DOIs
StatePublished - Jan 6 1995
Externally publishedYes

Keywords

  • Ascites
  • Laminin
  • Metastasis
  • Ovarian carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Byers, L. J., Osborne, J. L., Carson, L. F., Carter, J. R., Haney, A. F., Weinberg, J. B., & Ramakrishnan, S. (1995). Increased levels of laminin in ascitic fluid of patients with ovarian cancer. Cancer letters, 88(1), 67-72. https://doi.org/10.1016/0304-3835(94)03625-S