Increased functional connectivity common to symptomatic amyotrophic lateral sclerosis and those at genetic risk

Ricarda A L Menke, Malcolm Proudfoot, Joanne Wuu, Peter M. Andersen, Kevin Talbot, Michael G Benatar, Martin R. Turner

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Objective To discern presymptomatic changes in brain structure or function using advanced MRI in carriers of mutations predisposing to amyotrophic lateral sclerosis (ALS). Methods T1-weighted, diffusion weighted and resting state functional MRI data were acquired at 3 T for 12 asymptomatic mutation carriers ( psALS), 12 agematched controls and affected patients with ALS. Cortical thickness analysis, voxel-based morphometry, volumetric and shape analyses of subcortical structures, tract-based spatial statistics of metrics derived from the diffusion tensor, and resting state functional connectivity (FC) analyses were performed. Results Grey matter cortical thickness and shape analysis revealed significant atrophy in patients with ALS (but not psALS) compared with controls in the right primary motor cortex and right caudate. Comparison of diffusion tensor metrics showed widespread fractional anisotropy and radial diffusivity differences in patients with ALS compared to controls and the psALS group, encompassing parts of the corpus callosum, corticospinal tracts and superior longitudinal fasciculus. While FC in the resting-state sensorimotor network was similar in psALS and controls, FC between the cerebellum and a network comprising the precuneus, cingulate & middle frontal lobe was significantly higher in psALS and affected ALS compared to controls. Conclusions Rather than structural brain changes, increased FC may be among the earliest detectable brain abnormalities in asymptomatic carriers of ALS-causing gene mutations. With replication and significant refinement, this technique has potential in the future assessment of neuroprotective strategies.

Original languageEnglish (US)
Pages (from-to)580-588
Number of pages9
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume87
Issue number6
DOIs
StatePublished - Jun 1 2016

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Amyotrophic Lateral Sclerosis
Mutation
Brain
Parietal Lobe
Pyramidal Tracts
Corpus Callosum
Anisotropy
Motor Cortex
Frontal Lobe
Cerebellum
Atrophy
Genetic Risk
Connectivity
Magnetic Resonance Imaging
Control Groups
Genes
Carrier

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Surgery
  • Arts and Humanities (miscellaneous)

Cite this

Increased functional connectivity common to symptomatic amyotrophic lateral sclerosis and those at genetic risk. / Menke, Ricarda A L; Proudfoot, Malcolm; Wuu, Joanne; Andersen, Peter M.; Talbot, Kevin; Benatar, Michael G; Turner, Martin R.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 87, No. 6, 01.06.2016, p. 580-588.

Research output: Contribution to journalArticle

Menke, Ricarda A L ; Proudfoot, Malcolm ; Wuu, Joanne ; Andersen, Peter M. ; Talbot, Kevin ; Benatar, Michael G ; Turner, Martin R. / Increased functional connectivity common to symptomatic amyotrophic lateral sclerosis and those at genetic risk. In: Journal of Neurology, Neurosurgery and Psychiatry. 2016 ; Vol. 87, No. 6. pp. 580-588.
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