Increased expression of miRNA-146a in Alzheimer's disease transgenic mouse models

Y. Y. Li, J. G. Cui, J. M. Hill, S. Bhattacharjee, Y. Zhao, W. J. Lukiw

Research output: Contribution to journalArticlepeer-review

97 Scopus citations


A mouse and human brain-enriched micro-RNA-146a (miRNA-146a) is known to be important in modulating the innate immune response and inflammatory signaling in certain immunological and brain cell types. In this study we examined miRNA-146a levels in early-, moderate- and late-stage Alzheimer's disease (AD) neocortex and hippocampus, in several human primary brain and retinal cell lines, and in 5 different transgenic mouse models of AD including Tg2576, TgCRND8, PSAPP, 3xTg-AD and 5xFAD. Inducible expression of miRNA-146a was found to be significantly up-regulated in a primary co-culture of human neuronal-glial (HNG) cells stressed using interleukin1-beta (IL-1β), and this up-regulation was quenched using specific NF-k{cyrillic}B inhibitors including curcumin. Expression of miRNA-146a correlated with senile plaque density and synaptic pathology in Tg2576 and in 5xFAD transgenic mouse models used in the study of this common neurodegenerative disorder.

Original languageEnglish (US)
Pages (from-to)94-98
Number of pages5
JournalNeuroscience Letters
Issue number1
StatePublished - Jan 3 2011


  • 5xFAD
  • Alzheimer's disease
  • CAY10512
  • Curcumin
  • MiRNA-146a
  • Neurodegeneration
  • NF-κB
  • PDTC
  • Tg2576
  • Transgenic models of Alzheimer's disease

ASJC Scopus subject areas

  • Neuroscience(all)


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