Increased expression of miRNA-146a in Alzheimer's disease transgenic mouse models

Y. Y. Li, J. G. Cui, J. M. Hill, S. Bhattacharjee, Y. Zhao, W. J. Lukiw

Research output: Contribution to journalArticle

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Abstract

A mouse and human brain-enriched micro-RNA-146a (miRNA-146a) is known to be important in modulating the innate immune response and inflammatory signaling in certain immunological and brain cell types. In this study we examined miRNA-146a levels in early-, moderate- and late-stage Alzheimer's disease (AD) neocortex and hippocampus, in several human primary brain and retinal cell lines, and in 5 different transgenic mouse models of AD including Tg2576, TgCRND8, PSAPP, 3xTg-AD and 5xFAD. Inducible expression of miRNA-146a was found to be significantly up-regulated in a primary co-culture of human neuronal-glial (HNG) cells stressed using interleukin1-beta (IL-1β), and this up-regulation was quenched using specific NF-k{cyrillic}B inhibitors including curcumin. Expression of miRNA-146a correlated with senile plaque density and synaptic pathology in Tg2576 and in 5xFAD transgenic mouse models used in the study of this common neurodegenerative disorder.

Original languageEnglish
Pages (from-to)94-98
Number of pages5
JournalNeuroscience Letters
Volume487
Issue number1
DOIs
StatePublished - Jan 3 2011

Fingerprint

MicroRNAs
Transgenic Mice
Alzheimer Disease
Brain
Curcumin
Neocortex
Amyloid Plaques
Coculture Techniques
Innate Immunity
Neuroglia
Neurodegenerative Diseases
Hippocampus
Up-Regulation
Pathology
Cell Line

Keywords

  • 5xFAD
  • Alzheimer's disease
  • CAY10512
  • Curcumin
  • MiRNA-146a
  • Neurodegeneration
  • NF-κB
  • PDTC
  • Tg2576
  • Transgenic models of Alzheimer's disease

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Li, Y. Y., Cui, J. G., Hill, J. M., Bhattacharjee, S., Zhao, Y., & Lukiw, W. J. (2011). Increased expression of miRNA-146a in Alzheimer's disease transgenic mouse models. Neuroscience Letters, 487(1), 94-98. https://doi.org/10.1016/j.neulet.2010.09.079

Increased expression of miRNA-146a in Alzheimer's disease transgenic mouse models. / Li, Y. Y.; Cui, J. G.; Hill, J. M.; Bhattacharjee, S.; Zhao, Y.; Lukiw, W. J.

In: Neuroscience Letters, Vol. 487, No. 1, 03.01.2011, p. 94-98.

Research output: Contribution to journalArticle

Li, YY, Cui, JG, Hill, JM, Bhattacharjee, S, Zhao, Y & Lukiw, WJ 2011, 'Increased expression of miRNA-146a in Alzheimer's disease transgenic mouse models', Neuroscience Letters, vol. 487, no. 1, pp. 94-98. https://doi.org/10.1016/j.neulet.2010.09.079
Li, Y. Y. ; Cui, J. G. ; Hill, J. M. ; Bhattacharjee, S. ; Zhao, Y. ; Lukiw, W. J. / Increased expression of miRNA-146a in Alzheimer's disease transgenic mouse models. In: Neuroscience Letters. 2011 ; Vol. 487, No. 1. pp. 94-98.
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