Increased Cellular Responsiveness to Epinephrine in Primary Open-Angle Glaucoma

Paul F. Palmberg, Shirley Hajek, Dorothy Cooper, Bernard Becker

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The concentration of l-epinephrine hydrochloride necessary to inhibit lymphocyte transformation by 50% (I50 value) was determined in vitro for nine patients with primary open-angle glaucoma (POAG) and in seven controls. The lymphocytes of the patients with POAG were significantly (P<.05) more responsive. This result is consistent with the hypothesis that patients with POAG have an increased responsiveness to agents that elevate intracellular cyclic adenosine monophosphate levels.

Original languageEnglish (US)
Pages (from-to)855-856
Number of pages2
JournalArchives of ophthalmology
Volume95
Issue number5
DOIs
StatePublished - May 1977
Externally publishedYes

Keywords

  • Glaucoma
  • cyclic adenosine monophosphate
  • epinephrine hydrochloride
  • lymphocytes

ASJC Scopus subject areas

  • Ophthalmology

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