The concentration of l-epinephrine hydrochloride necessary to inhibit lymphocyte transformation by 50% (I50 value) was determined in vitro for nine patients with primary open-angle glaucoma (POAG) and in seven controls. The lymphocytes of the patients with POAG were significantly (P<.05) more responsive. This result is consistent with the hypothesis that patients with POAG have an increased responsiveness to agents that elevate intracellular cyclic adenosine monophosphate levels.
|Original language||English (US)|
|Number of pages||2|
|Journal||Archives of ophthalmology|
|State||Published - May 1977|
- cyclic adenosine monophosphate
- epinephrine hydrochloride
ASJC Scopus subject areas