Increased Cellular Responsiveness to Epinephrine in Primary Open-Angle Glaucoma

Paul F. Palmberg; Shirley Hajek; Dorothy Cooper; Bernard Becker

doi:10.1001/archopht.1977.04450050133016

Increased Cellular Responsiveness to Epinephrine in Primary Open-Angle Glaucoma

Paul F. Palmberg, Shirley Hajek, Dorothy Cooper, Bernard Becker

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The concentration of l-epinephrine hydrochloride necessary to inhibit lymphocyte transformation by 50% (I₅₀ value) was determined in vitro for nine patients with primary open-angle glaucoma (POAG) and in seven controls. The lymphocytes of the patients with POAG were significantly (P<.05) more responsive. This result is consistent with the hypothesis that patients with POAG have an increased responsiveness to agents that elevate intracellular cyclic adenosine monophosphate levels.

Original language	English (US)
Pages (from-to)	855-856
Number of pages	2
Journal	Archives of ophthalmology
Volume	95
Issue number	5
DOIs	https://doi.org/10.1001/archopht.1977.04450050133016
State	Published - May 1977
Externally published	Yes

Keywords

Glaucoma
cyclic adenosine monophosphate
epinephrine hydrochloride
lymphocytes

ASJC Scopus subject areas

Ophthalmology

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10.1001/archopht.1977.04450050133016

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abstract = "The concentration of l-epinephrine hydrochloride necessary to inhibit lymphocyte transformation by 50% (I50 value) was determined in vitro for nine patients with primary open-angle glaucoma (POAG) and in seven controls. The lymphocytes of the patients with POAG were significantly (P<.05) more responsive. This result is consistent with the hypothesis that patients with POAG have an increased responsiveness to agents that elevate intracellular cyclic adenosine monophosphate levels.",

keywords = "Glaucoma, cyclic adenosine monophosphate, epinephrine hydrochloride, lymphocytes",

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AU - Palmberg, Paul F.

AU - Hajek, Shirley

AU - Cooper, Dorothy

AU - Becker, Bernard

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Y1 - 1977/5

N2 - The concentration of l-epinephrine hydrochloride necessary to inhibit lymphocyte transformation by 50% (I50 value) was determined in vitro for nine patients with primary open-angle glaucoma (POAG) and in seven controls. The lymphocytes of the patients with POAG were significantly (P<.05) more responsive. This result is consistent with the hypothesis that patients with POAG have an increased responsiveness to agents that elevate intracellular cyclic adenosine monophosphate levels.

AB - The concentration of l-epinephrine hydrochloride necessary to inhibit lymphocyte transformation by 50% (I50 value) was determined in vitro for nine patients with primary open-angle glaucoma (POAG) and in seven controls. The lymphocytes of the patients with POAG were significantly (P<.05) more responsive. This result is consistent with the hypothesis that patients with POAG have an increased responsiveness to agents that elevate intracellular cyclic adenosine monophosphate levels.

KW - Glaucoma

KW - cyclic adenosine monophosphate

KW - epinephrine hydrochloride

KW - lymphocytes

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Increased Cellular Responsiveness to Epinephrine in Primary Open-Angle Glaucoma

Abstract

Keywords

ASJC Scopus subject areas

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