Increased cellular responsiveness to epinephrine in primary open-angle glaucoma

Paul Palmberg, S. Hajek, D. Cooper, B. Becker

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The concentration of l-epinephrine hydrochloride necessary to inhibit lymphocyte transformation by 50% (I50 value) was determined in vitro for nine patients with primary open-angle glaucoma (POAG) and in seven controls. The lymphocytes of the patients with POAG were significantly (P<.05) more responsive. This result is consistent with the hypothesis that patients with POAG have an increased responsiveness to agents that elevate intracellular cyclic adenosine monophosphate levels.

Original languageEnglish
Pages (from-to)855-856
Number of pages2
JournalArchives of Ophthalmology
Volume95
Issue number5
StatePublished - Dec 1 1977
Externally publishedYes

Fingerprint

Epinephrine
Lymphocyte Activation
Cyclic AMP
Lymphocytes
Primary Open Angle Glaucoma
In Vitro Techniques

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Increased cellular responsiveness to epinephrine in primary open-angle glaucoma. / Palmberg, Paul; Hajek, S.; Cooper, D.; Becker, B.

In: Archives of Ophthalmology, Vol. 95, No. 5, 01.12.1977, p. 855-856.

Research output: Contribution to journalArticle

Palmberg, Paul ; Hajek, S. ; Cooper, D. ; Becker, B. / Increased cellular responsiveness to epinephrine in primary open-angle glaucoma. In: Archives of Ophthalmology. 1977 ; Vol. 95, No. 5. pp. 855-856.
@article{2a82951fb6384ae3bb0d64049ed28fc9,
title = "Increased cellular responsiveness to epinephrine in primary open-angle glaucoma",
abstract = "The concentration of l-epinephrine hydrochloride necessary to inhibit lymphocyte transformation by 50{\%} (I50 value) was determined in vitro for nine patients with primary open-angle glaucoma (POAG) and in seven controls. The lymphocytes of the patients with POAG were significantly (P<.05) more responsive. This result is consistent with the hypothesis that patients with POAG have an increased responsiveness to agents that elevate intracellular cyclic adenosine monophosphate levels.",
author = "Paul Palmberg and S. Hajek and D. Cooper and B. Becker",
year = "1977",
month = "12",
day = "1",
language = "English",
volume = "95",
pages = "855--856",
journal = "JAMA Ophthalmology",
issn = "2168-6165",
publisher = "American Medical Association",
number = "5",

}

TY - JOUR

T1 - Increased cellular responsiveness to epinephrine in primary open-angle glaucoma

AU - Palmberg, Paul

AU - Hajek, S.

AU - Cooper, D.

AU - Becker, B.

PY - 1977/12/1

Y1 - 1977/12/1

N2 - The concentration of l-epinephrine hydrochloride necessary to inhibit lymphocyte transformation by 50% (I50 value) was determined in vitro for nine patients with primary open-angle glaucoma (POAG) and in seven controls. The lymphocytes of the patients with POAG were significantly (P<.05) more responsive. This result is consistent with the hypothesis that patients with POAG have an increased responsiveness to agents that elevate intracellular cyclic adenosine monophosphate levels.

AB - The concentration of l-epinephrine hydrochloride necessary to inhibit lymphocyte transformation by 50% (I50 value) was determined in vitro for nine patients with primary open-angle glaucoma (POAG) and in seven controls. The lymphocytes of the patients with POAG were significantly (P<.05) more responsive. This result is consistent with the hypothesis that patients with POAG have an increased responsiveness to agents that elevate intracellular cyclic adenosine monophosphate levels.

UR - http://www.scopus.com/inward/record.url?scp=0017610189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017610189&partnerID=8YFLogxK

M3 - Article

C2 - 193479

AN - SCOPUS:0017610189

VL - 95

SP - 855

EP - 856

JO - JAMA Ophthalmology

JF - JAMA Ophthalmology

SN - 2168-6165

IS - 5

ER -