Increased brain serotonin synthesis in migraine

D. C. Chugani, K. Niimura, Seemant Chaturvedi, O. Muzik, M. Fakhouri, M. L. Lee, H. T. Chugani

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Objective: To measure brain serotonin synthesis with PET using the tracer α-[11C]methyl-L-tryptophan in migraine patients. Background: Although the cause of migraine remains poorly understood, there is considerable evidence to support a role of the neurotransmitter serotonin in the pathophysiology of migraine. Methods: We studied 11 women (aged 33 ± 7.7 years) with a diagnosis of migraine according to International Headache Society criteria and 8 healthy women (aged 29 ± 9.2 years). Five patients were studied before and after chronic treatment with propranolol or nadolol. Results: Serotonin synthesis capacity (K-complex) values in migraine patients were higher than those measured in controls throughout the brain (p = 0.016); mean K-complex for whole brain was 0.0077 + 0.0020 mL/g/min in patients with migraine and 0.0054 ± 0.0003 mL/g/min in controls. The regional pattern did not differ between the two groups. However, the K-complex for whole brain in the subgroup of migraine patients with aura (n = 3) did not differ from that of the control group (p = 0.32). In the five patients studied twice (before and after treatment), we found a trend of increased whole-brain K-complex after drug treatment (p = 0.06). Conclusions: Our findings indicating increased brain serotonin synthesis capacity in migraine patients are consistent with previous reports of systemic alteration of serotonin metabolism in patients without aura. Our results also suggest that the mechanism of action of beta-adrenergic antagonists for migraine prophylaxis may involve regulation of serotonin synthesis.

Original languageEnglish (US)
Pages (from-to)1473-1479
Number of pages7
JournalNeurology
Volume53
Issue number7
StatePublished - Oct 22 1999
Externally publishedYes

Fingerprint

Migraine Disorders
Serotonin
Brain
Nadolol
Migraine with Aura
Adrenergic beta-Antagonists
Propranolol
Tryptophan
Neurotransmitter Agents
Headache
Epilepsy
Therapeutics
Control Groups
Pharmaceutical Preparations

Keywords

  • α-[C]methyl-L- tryptophan
  • Migraine
  • Neuroimaging
  • Positron emission tomography
  • Serotonin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Chugani, D. C., Niimura, K., Chaturvedi, S., Muzik, O., Fakhouri, M., Lee, M. L., & Chugani, H. T. (1999). Increased brain serotonin synthesis in migraine. Neurology, 53(7), 1473-1479.

Increased brain serotonin synthesis in migraine. / Chugani, D. C.; Niimura, K.; Chaturvedi, Seemant; Muzik, O.; Fakhouri, M.; Lee, M. L.; Chugani, H. T.

In: Neurology, Vol. 53, No. 7, 22.10.1999, p. 1473-1479.

Research output: Contribution to journalArticle

Chugani, DC, Niimura, K, Chaturvedi, S, Muzik, O, Fakhouri, M, Lee, ML & Chugani, HT 1999, 'Increased brain serotonin synthesis in migraine', Neurology, vol. 53, no. 7, pp. 1473-1479.
Chugani DC, Niimura K, Chaturvedi S, Muzik O, Fakhouri M, Lee ML et al. Increased brain serotonin synthesis in migraine. Neurology. 1999 Oct 22;53(7):1473-1479.
Chugani, D. C. ; Niimura, K. ; Chaturvedi, Seemant ; Muzik, O. ; Fakhouri, M. ; Lee, M. L. ; Chugani, H. T. / Increased brain serotonin synthesis in migraine. In: Neurology. 1999 ; Vol. 53, No. 7. pp. 1473-1479.
@article{d191c108f6c34f64a0b0f1b117c46af1,
title = "Increased brain serotonin synthesis in migraine",
abstract = "Objective: To measure brain serotonin synthesis with PET using the tracer α-[11C]methyl-L-tryptophan in migraine patients. Background: Although the cause of migraine remains poorly understood, there is considerable evidence to support a role of the neurotransmitter serotonin in the pathophysiology of migraine. Methods: We studied 11 women (aged 33 ± 7.7 years) with a diagnosis of migraine according to International Headache Society criteria and 8 healthy women (aged 29 ± 9.2 years). Five patients were studied before and after chronic treatment with propranolol or nadolol. Results: Serotonin synthesis capacity (K-complex) values in migraine patients were higher than those measured in controls throughout the brain (p = 0.016); mean K-complex for whole brain was 0.0077 + 0.0020 mL/g/min in patients with migraine and 0.0054 ± 0.0003 mL/g/min in controls. The regional pattern did not differ between the two groups. However, the K-complex for whole brain in the subgroup of migraine patients with aura (n = 3) did not differ from that of the control group (p = 0.32). In the five patients studied twice (before and after treatment), we found a trend of increased whole-brain K-complex after drug treatment (p = 0.06). Conclusions: Our findings indicating increased brain serotonin synthesis capacity in migraine patients are consistent with previous reports of systemic alteration of serotonin metabolism in patients without aura. Our results also suggest that the mechanism of action of beta-adrenergic antagonists for migraine prophylaxis may involve regulation of serotonin synthesis.",
keywords = "α-[C]methyl-L- tryptophan, Migraine, Neuroimaging, Positron emission tomography, Serotonin",
author = "Chugani, {D. C.} and K. Niimura and Seemant Chaturvedi and O. Muzik and M. Fakhouri and Lee, {M. L.} and Chugani, {H. T.}",
year = "1999",
month = "10",
day = "22",
language = "English (US)",
volume = "53",
pages = "1473--1479",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Increased brain serotonin synthesis in migraine

AU - Chugani, D. C.

AU - Niimura, K.

AU - Chaturvedi, Seemant

AU - Muzik, O.

AU - Fakhouri, M.

AU - Lee, M. L.

AU - Chugani, H. T.

PY - 1999/10/22

Y1 - 1999/10/22

N2 - Objective: To measure brain serotonin synthesis with PET using the tracer α-[11C]methyl-L-tryptophan in migraine patients. Background: Although the cause of migraine remains poorly understood, there is considerable evidence to support a role of the neurotransmitter serotonin in the pathophysiology of migraine. Methods: We studied 11 women (aged 33 ± 7.7 years) with a diagnosis of migraine according to International Headache Society criteria and 8 healthy women (aged 29 ± 9.2 years). Five patients were studied before and after chronic treatment with propranolol or nadolol. Results: Serotonin synthesis capacity (K-complex) values in migraine patients were higher than those measured in controls throughout the brain (p = 0.016); mean K-complex for whole brain was 0.0077 + 0.0020 mL/g/min in patients with migraine and 0.0054 ± 0.0003 mL/g/min in controls. The regional pattern did not differ between the two groups. However, the K-complex for whole brain in the subgroup of migraine patients with aura (n = 3) did not differ from that of the control group (p = 0.32). In the five patients studied twice (before and after treatment), we found a trend of increased whole-brain K-complex after drug treatment (p = 0.06). Conclusions: Our findings indicating increased brain serotonin synthesis capacity in migraine patients are consistent with previous reports of systemic alteration of serotonin metabolism in patients without aura. Our results also suggest that the mechanism of action of beta-adrenergic antagonists for migraine prophylaxis may involve regulation of serotonin synthesis.

AB - Objective: To measure brain serotonin synthesis with PET using the tracer α-[11C]methyl-L-tryptophan in migraine patients. Background: Although the cause of migraine remains poorly understood, there is considerable evidence to support a role of the neurotransmitter serotonin in the pathophysiology of migraine. Methods: We studied 11 women (aged 33 ± 7.7 years) with a diagnosis of migraine according to International Headache Society criteria and 8 healthy women (aged 29 ± 9.2 years). Five patients were studied before and after chronic treatment with propranolol or nadolol. Results: Serotonin synthesis capacity (K-complex) values in migraine patients were higher than those measured in controls throughout the brain (p = 0.016); mean K-complex for whole brain was 0.0077 + 0.0020 mL/g/min in patients with migraine and 0.0054 ± 0.0003 mL/g/min in controls. The regional pattern did not differ between the two groups. However, the K-complex for whole brain in the subgroup of migraine patients with aura (n = 3) did not differ from that of the control group (p = 0.32). In the five patients studied twice (before and after treatment), we found a trend of increased whole-brain K-complex after drug treatment (p = 0.06). Conclusions: Our findings indicating increased brain serotonin synthesis capacity in migraine patients are consistent with previous reports of systemic alteration of serotonin metabolism in patients without aura. Our results also suggest that the mechanism of action of beta-adrenergic antagonists for migraine prophylaxis may involve regulation of serotonin synthesis.

KW - α-[C]methyl-L- tryptophan

KW - Migraine

KW - Neuroimaging

KW - Positron emission tomography

KW - Serotonin

UR - http://www.scopus.com/inward/record.url?scp=0032716874&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032716874&partnerID=8YFLogxK

M3 - Article

VL - 53

SP - 1473

EP - 1479

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 7

ER -