Increased blood pressure can reduce fatigue of thenar muscles paralyzed after spinal cord injury

Jane E. Butler, Edith Ribot-Ciscar, Inge Zijdewind, Christine K Thomas

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The aim of this study was to evaluate whether increases in blood pressure, and presumably muscle perfusion pressure, improve the endurance of thenar muscles paralyzed chronically by cervical spinal cord injury (SCI). Resting mean arterial pressure (MAP) was low in all eight subjects (64 ± 2 mmHg). Muscle fatigue (force decline) was produced on 2 days by intermittent supramaximal electrical stimulation of the median nerve at 20 Hz for 2 min. During one of the fatigue tests, a concurrent sustained voluntary contraction of the contralateral elbow flexors was used to increase resting MAP (by 22%, on average). Although this change in blood pressure resulted in no significant change in mean fatigue for the group, changes in MAP with exercise (median nerve stimulation with and without voluntary contraction) correlated with changes in thenar muscle fatigue in seven subjects. For every 10% increase in MAP, fatigue was reduced by ∼3%. The data suggest that low blood pressure after chronic cervical SCI and poor blood pressure control during exercise exacerbate the fatigability of paralyzed muscles.

Original languageEnglish
Pages (from-to)575-584
Number of pages10
JournalMuscle and Nerve
Volume29
Issue number4
DOIs
StatePublished - Apr 1 2004

Fingerprint

Muscle Fatigue
Spinal Cord Injuries
Arterial Pressure
Blood Pressure
Fatigue
Median Nerve
Muscles
Elbow
Hypotension
Electric Stimulation
Perfusion
Pressure
Cervical Cord

Keywords

  • Fatigue
  • Muscle paralysis
  • Muscle perfusion pressure
  • Spinal cord injury
  • Systemic blood pressure

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Increased blood pressure can reduce fatigue of thenar muscles paralyzed after spinal cord injury. / Butler, Jane E.; Ribot-Ciscar, Edith; Zijdewind, Inge; Thomas, Christine K.

In: Muscle and Nerve, Vol. 29, No. 4, 01.04.2004, p. 575-584.

Research output: Contribution to journalArticle

Butler, Jane E. ; Ribot-Ciscar, Edith ; Zijdewind, Inge ; Thomas, Christine K. / Increased blood pressure can reduce fatigue of thenar muscles paralyzed after spinal cord injury. In: Muscle and Nerve. 2004 ; Vol. 29, No. 4. pp. 575-584.
@article{34c53a8a3d46460baafcc6e30d85b380,
title = "Increased blood pressure can reduce fatigue of thenar muscles paralyzed after spinal cord injury",
abstract = "The aim of this study was to evaluate whether increases in blood pressure, and presumably muscle perfusion pressure, improve the endurance of thenar muscles paralyzed chronically by cervical spinal cord injury (SCI). Resting mean arterial pressure (MAP) was low in all eight subjects (64 ± 2 mmHg). Muscle fatigue (force decline) was produced on 2 days by intermittent supramaximal electrical stimulation of the median nerve at 20 Hz for 2 min. During one of the fatigue tests, a concurrent sustained voluntary contraction of the contralateral elbow flexors was used to increase resting MAP (by 22{\%}, on average). Although this change in blood pressure resulted in no significant change in mean fatigue for the group, changes in MAP with exercise (median nerve stimulation with and without voluntary contraction) correlated with changes in thenar muscle fatigue in seven subjects. For every 10{\%} increase in MAP, fatigue was reduced by ∼3{\%}. The data suggest that low blood pressure after chronic cervical SCI and poor blood pressure control during exercise exacerbate the fatigability of paralyzed muscles.",
keywords = "Fatigue, Muscle paralysis, Muscle perfusion pressure, Spinal cord injury, Systemic blood pressure",
author = "Butler, {Jane E.} and Edith Ribot-Ciscar and Inge Zijdewind and Thomas, {Christine K}",
year = "2004",
month = "4",
day = "1",
doi = "10.1002/mus.20002",
language = "English",
volume = "29",
pages = "575--584",
journal = "Muscle and Nerve",
issn = "0148-639X",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Increased blood pressure can reduce fatigue of thenar muscles paralyzed after spinal cord injury

AU - Butler, Jane E.

AU - Ribot-Ciscar, Edith

AU - Zijdewind, Inge

AU - Thomas, Christine K

PY - 2004/4/1

Y1 - 2004/4/1

N2 - The aim of this study was to evaluate whether increases in blood pressure, and presumably muscle perfusion pressure, improve the endurance of thenar muscles paralyzed chronically by cervical spinal cord injury (SCI). Resting mean arterial pressure (MAP) was low in all eight subjects (64 ± 2 mmHg). Muscle fatigue (force decline) was produced on 2 days by intermittent supramaximal electrical stimulation of the median nerve at 20 Hz for 2 min. During one of the fatigue tests, a concurrent sustained voluntary contraction of the contralateral elbow flexors was used to increase resting MAP (by 22%, on average). Although this change in blood pressure resulted in no significant change in mean fatigue for the group, changes in MAP with exercise (median nerve stimulation with and without voluntary contraction) correlated with changes in thenar muscle fatigue in seven subjects. For every 10% increase in MAP, fatigue was reduced by ∼3%. The data suggest that low blood pressure after chronic cervical SCI and poor blood pressure control during exercise exacerbate the fatigability of paralyzed muscles.

AB - The aim of this study was to evaluate whether increases in blood pressure, and presumably muscle perfusion pressure, improve the endurance of thenar muscles paralyzed chronically by cervical spinal cord injury (SCI). Resting mean arterial pressure (MAP) was low in all eight subjects (64 ± 2 mmHg). Muscle fatigue (force decline) was produced on 2 days by intermittent supramaximal electrical stimulation of the median nerve at 20 Hz for 2 min. During one of the fatigue tests, a concurrent sustained voluntary contraction of the contralateral elbow flexors was used to increase resting MAP (by 22%, on average). Although this change in blood pressure resulted in no significant change in mean fatigue for the group, changes in MAP with exercise (median nerve stimulation with and without voluntary contraction) correlated with changes in thenar muscle fatigue in seven subjects. For every 10% increase in MAP, fatigue was reduced by ∼3%. The data suggest that low blood pressure after chronic cervical SCI and poor blood pressure control during exercise exacerbate the fatigability of paralyzed muscles.

KW - Fatigue

KW - Muscle paralysis

KW - Muscle perfusion pressure

KW - Spinal cord injury

KW - Systemic blood pressure

UR - http://www.scopus.com/inward/record.url?scp=1842477498&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1842477498&partnerID=8YFLogxK

U2 - 10.1002/mus.20002

DO - 10.1002/mus.20002

M3 - Article

VL - 29

SP - 575

EP - 584

JO - Muscle and Nerve

JF - Muscle and Nerve

SN - 0148-639X

IS - 4

ER -