Increased apolipoprotein C-III levels associated with insulin resistance contribute to dyslipidemia in normoglycemic and diabetic subjects from a triethnic population

Hermes Florez, Armando Mendez, Paul Casanova-Romero, Carmen Larreal-Urdaneta, Sumaya Castillo-Florez, David Lee, Ronald Goldberg

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Despite the major role of insulin in regulating apolipoprotein C-III (apo C-III) production, little is known about the relationship between apo C-III and insulin resistance. We examined this relationship, and the association of apo C-III with dyslipidemia, in a triethnic sample of 168 subjects with normoglycemia or type 2 diabetes. African-Americans had lower triglycerides (1.21 ± 0.11 mmol/l) compared with Hispanics (2.01 ± 0.14 mmol/l) and white non-Hispanics (1.83 ± 0.15 mmol/l), regardless of gender and type 2 diabetes status (P < 0.01), but this difference was partially accounted for by ethnic difference in apo C-III levels. Metabolic syndrome was associated with high apo C-III (>14 mg/dl) in Hispanics (OR = 5.6; 95%CI: 1.3-23.4) and white non-Hispanics (OR = 6.9; 95%CI: 1.3-36.4), but not in African-Americans. Apo C-III was the best predictor of triglycerides (R2 = 0.54, P < 0.001), after accounting for demographic and clinical variables. We found an inverse relationship between apo C-III levels and low-density lipoprotein (LDL) particle size in the type 2 diabetes subjects with (r = -0.36, P = 0.02) and without (r = -0.47, P = 0.02) the metabolic syndrome, but in normoglycemic subjects an inverse relationship was evident only in metabolic syndrome subjects (r = -0.52, P < 0.01). These results suggest that higher apo C-III may contribute to the increased cardiovascular risk in subjects with insulin resistance and type 2 diabetes through its effects on triglycerides and LDL particle size.

Original languageEnglish (US)
Pages (from-to)134-141
Number of pages8
JournalAtherosclerosis
Volume188
Issue number1
DOIs
StatePublished - Sep 1 2006

Keywords

  • Apolipoprotein C-III
  • Diabetes
  • Dyslipidemia
  • Insulin resistance
  • Metabolic syndrome
  • Small-dense low-density lipoprotein

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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