Increased Activation of 2′,3′-Dideoxycytidine by Acivicin

R. P. Agarwal

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The effect of acivicin (ACV) on cell growth, cell cycle progression, and intracellular accumulation of 2',3'-dideoxycytidine (ddC) was examined. Treatment of H9 cells with ACV (1 μM) plus ddC (25 μM) for 24 hrs inhibited cell growth to 74 ± 7%, arrested cells in the S phase, and increased the cellular ddC accumulation to 195-208% of control. The concentrations of ddCTP, the active form of ddC, was increased 3-4 fold in ACV treated cells.

Original languageEnglish (US)
Pages (from-to)1524-1529
Number of pages6
JournalBiochemical and biophysical research communications
Volume202
Issue number3
DOIs
StatePublished - Aug 15 1994

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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