Increased activation of 2',3'-dideoxycytidine by acivicin

R. P. Agarwal

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effect of acivicin (ACV) on cell growth, cell cycle progression, and intracellular accumulation of 2',3'-dideoxycytidine (ddC) was examined. Treatment of H9 cells with ACV (1 μM) plus ddC (25 μM) for 24 hrs inhibited cell growth to 74 ± 7%, arrested cells in the S phase, and increased the cellular ddC accumulation to 195-208% of control. The concentrations of ddCTP, the active form of ddC, was increased 3-4 fold in ACV treated cells.

Original languageEnglish
Pages (from-to)1524-1529
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume202
Issue number3
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

acivicin
Zalcitabine
Chemical activation
Cell growth
Cells
Growth
S Phase
Cell Cycle

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Increased activation of 2',3'-dideoxycytidine by acivicin. / Agarwal, R. P.

In: Biochemical and Biophysical Research Communications, Vol. 202, No. 3, 01.01.1994, p. 1524-1529.

Research output: Contribution to journalArticle

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