Increase in the frequency of histoplasmosis caused by HIV infection

M. A. Butt, E. G. Scerpella, J. N. Moreno, M. A. Fischl

Research output: Contribution to journalArticlepeer-review


Hypothesis: The increasing prevalence of HIV infection in areas non-endemic for histoplasmosts may cause an increase in the observed frequency of infections caused by Histoplasma capsulatum. Objectives: 1) to compare the incidence of histoptasmosis and HIV infection in Miami, a non-endemic area for Histopiasma, highly prevalent for HIV infection; 2) to describe the clinical presentation of histoplasmosts in a non-endemic area. Methods: Review of all cases of histoplasmosis diagnosed at the University of Miami Medical Center between 1986-1996. Incidence of HIV infection in Dade County obtained from surveillance reports. Results: There were 38 cases of histoplasmosis, 35 in HIV-seropositive subjects. The annual frequency of cases of histoplasmosis was directly correlated with the annual incidence of AIDS cases. In the figure, cases occurring in HIV-seropositive patients are depicted by the open bars. The continuous line depicts the number of AIDS cases reported annually in Dade County (line, right axis). Patients with histoplasmosis presented with advanced degrees of disease. Mean time from admission to diagnosis was 9.4 days. Conclusions: The high incidence of HIV infection in Miami may be responsible of the increase in the number of cases of histoplasmosis. A high index of suspicion is necessary to recognize histoplasmosis in non-endemic areas.

Original languageEnglish (US)
Number of pages1
JournalClinical Infectious Diseases
Issue number2
StatePublished - Dec 1 1997

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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