Increase in spontaneous motor activity following infusion of neurotensin into the ventral tegmental area

Peter W. Kalivas, Charles B. Nemeroff, Arthur J. Prange

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

Microinjection of neurotensin (NT) into the ventral tegmental area (VTA) of the rat produced a dose-dependent increase in spontaneous motor activity. The NT-induced hyperactivity consisted of an increase in exploratory behaviors, such as locomotion, rearing and sniffing, and a decrease in sleep or resting. The structural specificity of this response was demonstrated by microinjecting NT analogues and endogenous neuropeptides into the VTA. The fact that high levels of immunoreactive NT have been demonstrated in the VTA indicates that the observed behavioral effects may reflect an underlying physiological action by endogenous NT.

Original languageEnglish (US)
Pages (from-to)525-529
Number of pages5
JournalBrain Research
Volume229
Issue number2
DOIs
StatePublished - Dec 21 1981
Externally publishedYes

Keywords

  • microinjection
  • motor activity
  • neuropeptide
  • neurotensin
  • ventral tegmental area

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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