Increase in spontaneous motor activity following infusion of neurotensin into the ventral tegmental area

Peter W. Kalivas, Charles Nemeroff, Arthur J. Prange

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Microinjection of neurotensin (NT) into the ventral tegmental area (VTA) of the rat produced a dose-dependent increase in spontaneous motor activity. The NT-induced hyperactivity consisted of an increase in exploratory behaviors, such as locomotion, rearing and sniffing, and a decrease in sleep or resting. The structural specificity of this response was demonstrated by microinjecting NT analogues and endogenous neuropeptides into the VTA. The fact that high levels of immunoreactive NT have been demonstrated in the VTA indicates that the observed behavioral effects may reflect an underlying physiological action by endogenous NT.

Original languageEnglish
Pages (from-to)525-529
Number of pages5
JournalBrain Research
Volume229
Issue number2
DOIs
StatePublished - Dec 21 1981
Externally publishedYes

Fingerprint

Neurotensin
Ventral Tegmental Area
Motor Activity
Exploratory Behavior
Microinjections
Locomotion
Neuropeptides
Sleep

Keywords

  • microinjection
  • motor activity
  • neuropeptide
  • neurotensin
  • ventral tegmental area

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Increase in spontaneous motor activity following infusion of neurotensin into the ventral tegmental area. / Kalivas, Peter W.; Nemeroff, Charles; Prange, Arthur J.

In: Brain Research, Vol. 229, No. 2, 21.12.1981, p. 525-529.

Research output: Contribution to journalArticle

@article{93ff489bc91b4a639b53ce57cf9239d6,
title = "Increase in spontaneous motor activity following infusion of neurotensin into the ventral tegmental area",
abstract = "Microinjection of neurotensin (NT) into the ventral tegmental area (VTA) of the rat produced a dose-dependent increase in spontaneous motor activity. The NT-induced hyperactivity consisted of an increase in exploratory behaviors, such as locomotion, rearing and sniffing, and a decrease in sleep or resting. The structural specificity of this response was demonstrated by microinjecting NT analogues and endogenous neuropeptides into the VTA. The fact that high levels of immunoreactive NT have been demonstrated in the VTA indicates that the observed behavioral effects may reflect an underlying physiological action by endogenous NT.",
keywords = "microinjection, motor activity, neuropeptide, neurotensin, ventral tegmental area",
author = "Kalivas, {Peter W.} and Charles Nemeroff and Prange, {Arthur J.}",
year = "1981",
month = "12",
day = "21",
doi = "10.1016/0006-8993(81)91016-7",
language = "English",
volume = "229",
pages = "525--529",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Increase in spontaneous motor activity following infusion of neurotensin into the ventral tegmental area

AU - Kalivas, Peter W.

AU - Nemeroff, Charles

AU - Prange, Arthur J.

PY - 1981/12/21

Y1 - 1981/12/21

N2 - Microinjection of neurotensin (NT) into the ventral tegmental area (VTA) of the rat produced a dose-dependent increase in spontaneous motor activity. The NT-induced hyperactivity consisted of an increase in exploratory behaviors, such as locomotion, rearing and sniffing, and a decrease in sleep or resting. The structural specificity of this response was demonstrated by microinjecting NT analogues and endogenous neuropeptides into the VTA. The fact that high levels of immunoreactive NT have been demonstrated in the VTA indicates that the observed behavioral effects may reflect an underlying physiological action by endogenous NT.

AB - Microinjection of neurotensin (NT) into the ventral tegmental area (VTA) of the rat produced a dose-dependent increase in spontaneous motor activity. The NT-induced hyperactivity consisted of an increase in exploratory behaviors, such as locomotion, rearing and sniffing, and a decrease in sleep or resting. The structural specificity of this response was demonstrated by microinjecting NT analogues and endogenous neuropeptides into the VTA. The fact that high levels of immunoreactive NT have been demonstrated in the VTA indicates that the observed behavioral effects may reflect an underlying physiological action by endogenous NT.

KW - microinjection

KW - motor activity

KW - neuropeptide

KW - neurotensin

KW - ventral tegmental area

UR - http://www.scopus.com/inward/record.url?scp=0019774574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019774574&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(81)91016-7

DO - 10.1016/0006-8993(81)91016-7

M3 - Article

C2 - 7306825

AN - SCOPUS:0019774574

VL - 229

SP - 525

EP - 529

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -