Increase in Plasma Growth Hormone (GH)-Like Activity After Administration of Porcine GH-Releasing Hormone

Eugenio E. Muller, Andrew V Schally, Daniela Cocchi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The ability of pure growth hormone (GH)-releasing hormone (GH-RH) to deplete pituitary GH content and simultaneously to increase plasma GH-like activity was investigated in the rat using the “tibia test” method. GH-RH (350 ng) induced a significant fall in pituitary GH content which was accompanied by increased GH-like activity in plasma. GH-RH administered at two dose levels, 80 and 400 ng, induced a dose-related fall in pituitary GH. There was a concomitant rise in plasma GH-like activity of rats given the larger dose. Plasma GH-like activity in rats injected with saline was not detectable. These results indicate that the pituitary depletion of GH content in rats caused by GH-RH reflects true release of the hormone.

Original languageEnglish (US)
Pages (from-to)489-494
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Volume137
Issue number2
DOIs
StatePublished - 1971
Externally publishedYes

Fingerprint

Growth Hormone-Releasing Hormone
Growth Hormone
Swine
Plasmas
Rats
Tibia
Thermodynamic properties
Hormones

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Increase in Plasma Growth Hormone (GH)-Like Activity After Administration of Porcine GH-Releasing Hormone. / Muller, Eugenio E.; Schally, Andrew V; Cocchi, Daniela.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 137, No. 2, 1971, p. 489-494.

Research output: Contribution to journalArticle

@article{65ab28f0071347dda38ec16cb133489b,
title = "Increase in Plasma Growth Hormone (GH)-Like Activity After Administration of Porcine GH-Releasing Hormone",
abstract = "The ability of pure growth hormone (GH)-releasing hormone (GH-RH) to deplete pituitary GH content and simultaneously to increase plasma GH-like activity was investigated in the rat using the “tibia test” method. GH-RH (350 ng) induced a significant fall in pituitary GH content which was accompanied by increased GH-like activity in plasma. GH-RH administered at two dose levels, 80 and 400 ng, induced a dose-related fall in pituitary GH. There was a concomitant rise in plasma GH-like activity of rats given the larger dose. Plasma GH-like activity in rats injected with saline was not detectable. These results indicate that the pituitary depletion of GH content in rats caused by GH-RH reflects true release of the hormone.",
author = "Muller, {Eugenio E.} and Schally, {Andrew V} and Daniela Cocchi",
year = "1971",
doi = "10.3181/00379727-137-35606",
language = "English (US)",
volume = "137",
pages = "489--494",
journal = "Experimental Biology and Medicine",
issn = "0037-9727",
publisher = "Society for Experimental Biology and Medicine",
number = "2",

}

TY - JOUR

T1 - Increase in Plasma Growth Hormone (GH)-Like Activity After Administration of Porcine GH-Releasing Hormone

AU - Muller, Eugenio E.

AU - Schally, Andrew V

AU - Cocchi, Daniela

PY - 1971

Y1 - 1971

N2 - The ability of pure growth hormone (GH)-releasing hormone (GH-RH) to deplete pituitary GH content and simultaneously to increase plasma GH-like activity was investigated in the rat using the “tibia test” method. GH-RH (350 ng) induced a significant fall in pituitary GH content which was accompanied by increased GH-like activity in plasma. GH-RH administered at two dose levels, 80 and 400 ng, induced a dose-related fall in pituitary GH. There was a concomitant rise in plasma GH-like activity of rats given the larger dose. Plasma GH-like activity in rats injected with saline was not detectable. These results indicate that the pituitary depletion of GH content in rats caused by GH-RH reflects true release of the hormone.

AB - The ability of pure growth hormone (GH)-releasing hormone (GH-RH) to deplete pituitary GH content and simultaneously to increase plasma GH-like activity was investigated in the rat using the “tibia test” method. GH-RH (350 ng) induced a significant fall in pituitary GH content which was accompanied by increased GH-like activity in plasma. GH-RH administered at two dose levels, 80 and 400 ng, induced a dose-related fall in pituitary GH. There was a concomitant rise in plasma GH-like activity of rats given the larger dose. Plasma GH-like activity in rats injected with saline was not detectable. These results indicate that the pituitary depletion of GH content in rats caused by GH-RH reflects true release of the hormone.

UR - http://www.scopus.com/inward/record.url?scp=84918747770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84918747770&partnerID=8YFLogxK

U2 - 10.3181/00379727-137-35606

DO - 10.3181/00379727-137-35606

M3 - Article

AN - SCOPUS:84918747770

VL - 137

SP - 489

EP - 494

JO - Experimental Biology and Medicine

JF - Experimental Biology and Medicine

SN - 0037-9727

IS - 2

ER -