Increase in Plasma Growth Hormone (GH)-Like Activity After Administration of Porcine GH-Releasing Hormone

Eugenio E. Muller, Andrew V. Schally, Daniela Cocchi

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The ability of pure growth hormone (GH)-releasing hormone (GH-RH) to deplete pituitary GH content and simultaneously to increase plasma GH-like activity was investigated in the rat using the “tibia test” method. GH-RH (350 ng) induced a significant fall in pituitary GH content which was accompanied by increased GH-like activity in plasma. GH-RH administered at two dose levels, 80 and 400 ng, induced a dose-related fall in pituitary GH. There was a concomitant rise in plasma GH-like activity of rats given the larger dose. Plasma GH-like activity in rats injected with saline was not detectable. These results indicate that the pituitary depletion of GH content in rats caused by GH-RH reflects true release of the hormone.

Original languageEnglish (US)
Pages (from-to)489-494
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Volume137
Issue number2
DOIs
StatePublished - Jun 1971
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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