Increase in basal and thyrotropin-releasing hormone (trh)-stimulated secretion of thyrotropin (TSH) by passive immunization with antiserum to somatostatin in rats

Akira Arimura, Andrew V. Schally

Research output: Contribution to journalArticle

91 Scopus citations

Abstract

Passive immunization of rats with an antiserum to synthetic somatostatin caused a 250% elevation of basal serum TSH levels and a nearly 200% increase in TSH response to TRH. These findings strongly support the concept that pituitary thyrotrophs are regulated by endogenous somatostatin as well as by TRH and thyroid hormones. Serum GH levels in the antiserum treated rats were considerably higher than those in rats which received normal serum. No clearcut influence on prolactin secretion was observed.

Original languageEnglish (US)
Pages (from-to)1069-1072
Number of pages4
JournalEndocrinology
Volume98
Issue number4
DOIs
StatePublished - Apr 1976
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology

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