Inclusion body myositis in twins

Anthony A. Amato, Robert T. Shebert

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Sporadic inclusion body myositis (s-IBM) is characterized by late onset of slowly progressive weakness that involves the quadriceps and volar forearm muscles early in the course of the disease. There are hereditary forms of inclusion body myopathy (h-IBM) that histologically resemble s-IBM. The lack of inflammation on biopsy and the different ages at onset and patterns of muscle weakness distinguish s-IBM from h-IBM. We report twin brothers with the typical clinical and histologic features of s-IBM. The occurrence of s- IBM in these twins suggests the possibility of a genetic susceptibility to developing s-IBM.

Original languageEnglish (US)
Pages (from-to)598-600
Number of pages3
Issue number2
StatePublished - Aug 1998

ASJC Scopus subject areas

  • Clinical Neurology


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