Abstract
Background: We sought to define current incidence trends and outcomes for children with lung and bronchus tumors. Methods: The SEER registry was queried from 1973 to 2004 for all patients with pulmonary tumors less than 20 y of age. Results: Overall, 160 patients were identified. The age-adjusted incidence has remained stable at 0.049 per 100,000 persons. The median age at diagnosis was 16 y. Whites had the highest age-adjusted population incidence at 0.056 per 100,000. Most tumors arose in the lower lobe (37%), followed by the upper lobe (31.2%). The most common histology was endocrine tumor (51.6%), followed by sarcoma (11%), and mucoepidermoid tumor (9%). Overall survival was greater than 381 mo with a 15-y survival of 65%. Males had better survival (>381 versus 288 months). Endocrine and mucoepidermoid tumors had the best survival. Small cell carcinoma had the worst median survival at less than 5 mo. Squamous cell carcinoma and adenocarcinoma both had a 14-mo median survival. Median survival for nonsurgically treated patients was 14 mo with a 10-y survival rate of 32%. Surgery improved the 10-y survival to 75% (P < 0.0001). Multivariate analysis demonstrated nonsurgical treatment and nonendocrine tumor histology to be independent prognostic factors of death. Conclusion: The incidence of pediatric lung cancer remains stable. Several factors, including nonsurgical treatment and nonendocrine tumors confer a poor prognosis. Early diagnosis and surgical therapy provide the best chance for survival.
| Original language | English |
|---|---|
| Pages (from-to) | 224-230 |
| Number of pages | 7 |
| Journal | Journal of Surgical Research |
| Volume | 156 |
| Issue number | 2 |
| DOIs | |
| State | Published - Oct 1 2009 |
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Keywords
- lung cancer
- outcomes
- pediatric
- SEER
- tumor
ASJC Scopus subject areas
- Surgery
Cite this
Incidence and Outcomes of Malignant Pediatric Lung Neoplasms. / Neville, Holly; Hogan, Anthony Richard; Zhuge, Ying; Perez, Eduardo; Cheung, Michael C.; Koniaris, Leonidas G.; Thompson, William R.; Sola, Juan E.
In: Journal of Surgical Research, Vol. 156, No. 2, 01.10.2009, p. 224-230.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Incidence and Outcomes of Malignant Pediatric Lung Neoplasms
AU - Neville, Holly
AU - Hogan, Anthony Richard
AU - Zhuge, Ying
AU - Perez, Eduardo
AU - Cheung, Michael C.
AU - Koniaris, Leonidas G.
AU - Thompson, William R.
AU - Sola, Juan E
PY - 2009/10/1
Y1 - 2009/10/1
N2 - Background: We sought to define current incidence trends and outcomes for children with lung and bronchus tumors. Methods: The SEER registry was queried from 1973 to 2004 for all patients with pulmonary tumors less than 20 y of age. Results: Overall, 160 patients were identified. The age-adjusted incidence has remained stable at 0.049 per 100,000 persons. The median age at diagnosis was 16 y. Whites had the highest age-adjusted population incidence at 0.056 per 100,000. Most tumors arose in the lower lobe (37%), followed by the upper lobe (31.2%). The most common histology was endocrine tumor (51.6%), followed by sarcoma (11%), and mucoepidermoid tumor (9%). Overall survival was greater than 381 mo with a 15-y survival of 65%. Males had better survival (>381 versus 288 months). Endocrine and mucoepidermoid tumors had the best survival. Small cell carcinoma had the worst median survival at less than 5 mo. Squamous cell carcinoma and adenocarcinoma both had a 14-mo median survival. Median survival for nonsurgically treated patients was 14 mo with a 10-y survival rate of 32%. Surgery improved the 10-y survival to 75% (P < 0.0001). Multivariate analysis demonstrated nonsurgical treatment and nonendocrine tumor histology to be independent prognostic factors of death. Conclusion: The incidence of pediatric lung cancer remains stable. Several factors, including nonsurgical treatment and nonendocrine tumors confer a poor prognosis. Early diagnosis and surgical therapy provide the best chance for survival.
AB - Background: We sought to define current incidence trends and outcomes for children with lung and bronchus tumors. Methods: The SEER registry was queried from 1973 to 2004 for all patients with pulmonary tumors less than 20 y of age. Results: Overall, 160 patients were identified. The age-adjusted incidence has remained stable at 0.049 per 100,000 persons. The median age at diagnosis was 16 y. Whites had the highest age-adjusted population incidence at 0.056 per 100,000. Most tumors arose in the lower lobe (37%), followed by the upper lobe (31.2%). The most common histology was endocrine tumor (51.6%), followed by sarcoma (11%), and mucoepidermoid tumor (9%). Overall survival was greater than 381 mo with a 15-y survival of 65%. Males had better survival (>381 versus 288 months). Endocrine and mucoepidermoid tumors had the best survival. Small cell carcinoma had the worst median survival at less than 5 mo. Squamous cell carcinoma and adenocarcinoma both had a 14-mo median survival. Median survival for nonsurgically treated patients was 14 mo with a 10-y survival rate of 32%. Surgery improved the 10-y survival to 75% (P < 0.0001). Multivariate analysis demonstrated nonsurgical treatment and nonendocrine tumor histology to be independent prognostic factors of death. Conclusion: The incidence of pediatric lung cancer remains stable. Several factors, including nonsurgical treatment and nonendocrine tumors confer a poor prognosis. Early diagnosis and surgical therapy provide the best chance for survival.
KW - lung cancer
KW - outcomes
KW - pediatric
KW - SEER
KW - tumor
UR - http://www.scopus.com/inward/record.url?scp=70249107720&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70249107720&partnerID=8YFLogxK
U2 - 10.1016/j.jss.2009.03.100
DO - 10.1016/j.jss.2009.03.100
M3 - Article
C2 - 19631347
AN - SCOPUS:70249107720
VL - 156
SP - 224
EP - 230
JO - Journal of Surgical Research
JF - Journal of Surgical Research
SN - 0022-4804
IS - 2
ER -