Inactivation of C1 in rheumatoid synovial fluid, purified C1 and C1 esterase, by gold compounds

D. R. Schultz, J. E. Volanakis, P. I. Arnold

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41 Scopus citations


The effects of gold compounds on the functional activities of rheumatoid synovial fluid and normal serum C1, C4, and C2 were investigated in vitro. Commercial and purified gold sodium thiomalate in concentrations, as low as 1.25 μg/ml (expressed as elemental gold) inactivated native C1 and highly purified C1s, whereas equivalent or higher concentrations of thiomalate had no effect. C1 inactivation was caused also by other gold compounds such as gold chloride and gold sodium thiosulphate. The C1 inactivation was not reversible following extensive dialysis. The partial protection of C4 and C2, the two natural substrates for C1, indirectly verified the C1 inactivation. This is the first study to show that gold compounds inactivate C1, one of the reactants in the pathogenesis and/or perpetuation of rheumatoid arthritis.

Original languageEnglish (US)
Pages (from-to)395-406
Number of pages12
JournalClinical and Experimental Immunology
Issue number3
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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