Inactivation of C1 in rheumatoid synovial fluid, purified C1 and C1 esterase, by gold compounds

D. R. Schultz, J. E. Volanakis, P. I. Arnold

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The effects of gold compounds on the functional activities of rheumatoid synovial fluid and normal serum C1, C4, and C2 were investigated in vitro. Commercial and purified gold sodium thiomalate in concentrations, as low as 1.25 μg/ml (expressed as elemental gold) inactivated native C1 and highly purified C1s, whereas equivalent or higher concentrations of thiomalate had no effect. C1 inactivation was caused also by other gold compounds such as gold chloride and gold sodium thiosulphate. The C1 inactivation was not reversible following extensive dialysis. The partial protection of C4 and C2, the two natural substrates for C1, indirectly verified the C1 inactivation. This is the first study to show that gold compounds inactivate C1, one of the reactants in the pathogenesis and/or perpetuation of rheumatoid arthritis.

Original languageEnglish
Pages (from-to)395-406
Number of pages12
JournalClinical and Experimental Immunology
Volume17
Issue number3
StatePublished - Dec 1 1974
Externally publishedYes

Fingerprint

Complement C1s
Gold Compounds
Synovial Fluid
Thiomalates
Gold Sodium Thiosulfate
Gold Sodium Thiomalate
Gold
Dialysis
Rheumatoid Arthritis
Serum

ASJC Scopus subject areas

  • Immunology

Cite this

Inactivation of C1 in rheumatoid synovial fluid, purified C1 and C1 esterase, by gold compounds. / Schultz, D. R.; Volanakis, J. E.; Arnold, P. I.

In: Clinical and Experimental Immunology, Vol. 17, No. 3, 01.12.1974, p. 395-406.

Research output: Contribution to journalArticle

Schultz, D. R. ; Volanakis, J. E. ; Arnold, P. I. / Inactivation of C1 in rheumatoid synovial fluid, purified C1 and C1 esterase, by gold compounds. In: Clinical and Experimental Immunology. 1974 ; Vol. 17, No. 3. pp. 395-406.
@article{7ac76e55fa3649bf8c8554bef1028fab,
title = "Inactivation of C1 in rheumatoid synovial fluid, purified C1 and C1 esterase, by gold compounds",
abstract = "The effects of gold compounds on the functional activities of rheumatoid synovial fluid and normal serum C1, C4, and C2 were investigated in vitro. Commercial and purified gold sodium thiomalate in concentrations, as low as 1.25 μg/ml (expressed as elemental gold) inactivated native C1 and highly purified C1s, whereas equivalent or higher concentrations of thiomalate had no effect. C1 inactivation was caused also by other gold compounds such as gold chloride and gold sodium thiosulphate. The C1 inactivation was not reversible following extensive dialysis. The partial protection of C4 and C2, the two natural substrates for C1, indirectly verified the C1 inactivation. This is the first study to show that gold compounds inactivate C1, one of the reactants in the pathogenesis and/or perpetuation of rheumatoid arthritis.",
author = "Schultz, {D. R.} and Volanakis, {J. E.} and Arnold, {P. I.}",
year = "1974",
month = "12",
day = "1",
language = "English",
volume = "17",
pages = "395--406",
journal = "Clinical and Experimental Immunology",
issn = "0009-9104",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Inactivation of C1 in rheumatoid synovial fluid, purified C1 and C1 esterase, by gold compounds

AU - Schultz, D. R.

AU - Volanakis, J. E.

AU - Arnold, P. I.

PY - 1974/12/1

Y1 - 1974/12/1

N2 - The effects of gold compounds on the functional activities of rheumatoid synovial fluid and normal serum C1, C4, and C2 were investigated in vitro. Commercial and purified gold sodium thiomalate in concentrations, as low as 1.25 μg/ml (expressed as elemental gold) inactivated native C1 and highly purified C1s, whereas equivalent or higher concentrations of thiomalate had no effect. C1 inactivation was caused also by other gold compounds such as gold chloride and gold sodium thiosulphate. The C1 inactivation was not reversible following extensive dialysis. The partial protection of C4 and C2, the two natural substrates for C1, indirectly verified the C1 inactivation. This is the first study to show that gold compounds inactivate C1, one of the reactants in the pathogenesis and/or perpetuation of rheumatoid arthritis.

AB - The effects of gold compounds on the functional activities of rheumatoid synovial fluid and normal serum C1, C4, and C2 were investigated in vitro. Commercial and purified gold sodium thiomalate in concentrations, as low as 1.25 μg/ml (expressed as elemental gold) inactivated native C1 and highly purified C1s, whereas equivalent or higher concentrations of thiomalate had no effect. C1 inactivation was caused also by other gold compounds such as gold chloride and gold sodium thiosulphate. The C1 inactivation was not reversible following extensive dialysis. The partial protection of C4 and C2, the two natural substrates for C1, indirectly verified the C1 inactivation. This is the first study to show that gold compounds inactivate C1, one of the reactants in the pathogenesis and/or perpetuation of rheumatoid arthritis.

UR - http://www.scopus.com/inward/record.url?scp=0016203415&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016203415&partnerID=8YFLogxK

M3 - Article

C2 - 4219842

AN - SCOPUS:0016203415

VL - 17

SP - 395

EP - 406

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

SN - 0009-9104

IS - 3

ER -