In vivo 1H magnetic resonance imaging and spectroscopy of the rat spinal cord using an inductively-coupled chronically implanted RF coil

X. Silver, W. Xu Ni, E. V. Mercer, B. L. Beck, Elizabeth Bossart, B. Inglis, T. H. Mareci

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

An inductively coupled, chronically implanted short-solenoid coil was used to obtain in vivo localized 1H NMR spectra and diffusion-weighted images from a rat spinal cord. A 5 × 8 mm two-turn elliptically shaped solenoid coil was implanted in rats at the site of a T-12 vertebral-level laminectomy. Excitation was achieved solely by a 3 × 3 cm external surface coil, and signal detection was achieved by inductively coupling the external coil to the implanted coil. The image signal-to-noise ratio (SNR) obtained with the inductively-coupled implanted coil was compared with that obtained using a linear or a quadrature external surface coil. The implanted coil provided a gain by over a factor of 3 in SNR. The implanted coil was used to measure localized 1H spectra in vivo at the T13/L1 spinal-cord level within a 1.85 × 1.85 × 4.82 mm (16.5 μL) volume. With 256 averages, a ∼3-s repetition delay and respiratory gating, a high-quality spectrum was acquired in 13 min. In addition, water translational diffusion was measured in three orthogonal directions using a stimulated-echo imaging sequence, with a short echo time (TE), to produce a quantitative map of diffusion in a rat spinal cord in vivo.

Original languageEnglish
Pages (from-to)1216-1222
Number of pages7
JournalMagnetic Resonance in Medicine
Volume46
Issue number6
DOIs
StatePublished - Dec 12 2001
Externally publishedYes

Fingerprint

Spinal Cord
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Signal-To-Noise Ratio
Laminectomy
Water
Direction compound
Proton Magnetic Resonance Spectroscopy

Keywords

  • Implanted coils
  • MRI
  • NMR
  • Spectroscopy
  • Spinal cord

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

In vivo 1H magnetic resonance imaging and spectroscopy of the rat spinal cord using an inductively-coupled chronically implanted RF coil. / Silver, X.; Ni, W. Xu; Mercer, E. V.; Beck, B. L.; Bossart, Elizabeth; Inglis, B.; Mareci, T. H.

In: Magnetic Resonance in Medicine, Vol. 46, No. 6, 12.12.2001, p. 1216-1222.

Research output: Contribution to journalArticle

Silver, X. ; Ni, W. Xu ; Mercer, E. V. ; Beck, B. L. ; Bossart, Elizabeth ; Inglis, B. ; Mareci, T. H. / In vivo 1H magnetic resonance imaging and spectroscopy of the rat spinal cord using an inductively-coupled chronically implanted RF coil. In: Magnetic Resonance in Medicine. 2001 ; Vol. 46, No. 6. pp. 1216-1222.
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