In vivo stereological assessment of caudate volume in man: Effect of normal aging

K. Ranga Krishnan, M. M. Husain, W. M. McDonald, P. M. Doraiswamy, G. S. Figiel, O. B. Boyko, E. H. Ellinwood, C. B. Nemeroff

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


Using intermediate weighted magnetic resonance imaging (MRI) and a systematic sampling stereological method in 39 normal volunteers aged 24-79 years old, we demonstrated a marked age-associated decline in caudate nuclei volume (r = -0.69, p < 0.0001). The mean absolute volume of the caudate nuclei in this study (9.4 cm3) was almost identical to that reported in a previous autopsy study and further confirms the validity of this stereological technique for use with MR images. This technique will provide a method for measuring the caudate and other nuclei in vivo, from brain images and, as such, a research tool to correlate age-associated changes in cognitive, sensory and motor function with caudate nucleus volume and other brain regions.

Original languageEnglish (US)
Pages (from-to)1325-1329
Number of pages5
JournalLife Sciences
Issue number15
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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