Abstract
Refocused insensitive nucleus enhancement by polarization transfer (RINEPT) from protons (1H) to a J-coupled phosphorus (31P) has been incorporated into three-dimensional (3D) chemical-shift-imaging (CSI) sequence on a clinical imager. The technique is demonstrated on a phantom and in in vivo human brain. The polarization-transfer efficiency (~1.2) is lower than the theoretical maximum of γ1(H)/γ31(P) ≃ 2.4 resulting from 1H- 1H homonuclear J couplings of similar magnitude competing with the 1H → 31P transfer. Nevertheless, compared with direct 31P Ernst-angle excitation, signal gains of up to x1.8 were obtained mainly as a result of T1 differences between 31P and the 1H. Spectral interpretation is simplified by editing out all non-proton-coupled 31P signals. The duration, ~50 min, and power deposition, ~1 W · kg-1, make the application suitable for human studies.
| Original language | English |
|---|---|
| Pages (from-to) | 301-306 |
| Number of pages | 6 |
| Journal | Magnetic Resonance in Medicine |
| Volume | 37 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 1997 |
| Externally published | Yes |
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Keywords
- 3D CSI
- phosphorus
- polarization transfer
- proton decoupling
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
In vivo phosphorus polarization transfer and decoupling from protons in three-dimensional localized nuclear magnetic resonance spectroscopy of human brain. / Gonen, Oded; Mohebbi, Afsaneh; Stoyanova, Radka; Brown, Truman R.
In: Magnetic Resonance in Medicine, Vol. 37, No. 2, 01.02.1997, p. 301-306.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vivo phosphorus polarization transfer and decoupling from protons in three-dimensional localized nuclear magnetic resonance spectroscopy of human brain
AU - Gonen, Oded
AU - Mohebbi, Afsaneh
AU - Stoyanova, Radka
AU - Brown, Truman R.
PY - 1997/2/1
Y1 - 1997/2/1
N2 - Refocused insensitive nucleus enhancement by polarization transfer (RINEPT) from protons (1H) to a J-coupled phosphorus (31P) has been incorporated into three-dimensional (3D) chemical-shift-imaging (CSI) sequence on a clinical imager. The technique is demonstrated on a phantom and in in vivo human brain. The polarization-transfer efficiency (~1.2) is lower than the theoretical maximum of γ1(H)/γ31(P) ≃ 2.4 resulting from 1H- 1H homonuclear J couplings of similar magnitude competing with the 1H → 31P transfer. Nevertheless, compared with direct 31P Ernst-angle excitation, signal gains of up to x1.8 were obtained mainly as a result of T1 differences between 31P and the 1H. Spectral interpretation is simplified by editing out all non-proton-coupled 31P signals. The duration, ~50 min, and power deposition, ~1 W · kg-1, make the application suitable for human studies.
AB - Refocused insensitive nucleus enhancement by polarization transfer (RINEPT) from protons (1H) to a J-coupled phosphorus (31P) has been incorporated into three-dimensional (3D) chemical-shift-imaging (CSI) sequence on a clinical imager. The technique is demonstrated on a phantom and in in vivo human brain. The polarization-transfer efficiency (~1.2) is lower than the theoretical maximum of γ1(H)/γ31(P) ≃ 2.4 resulting from 1H- 1H homonuclear J couplings of similar magnitude competing with the 1H → 31P transfer. Nevertheless, compared with direct 31P Ernst-angle excitation, signal gains of up to x1.8 were obtained mainly as a result of T1 differences between 31P and the 1H. Spectral interpretation is simplified by editing out all non-proton-coupled 31P signals. The duration, ~50 min, and power deposition, ~1 W · kg-1, make the application suitable for human studies.
KW - 3D CSI
KW - phosphorus
KW - polarization transfer
KW - proton decoupling
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UR - http://www.scopus.com/inward/citedby.url?scp=0031012958&partnerID=8YFLogxK
U2 - 10.1002/mrm.1910370228
DO - 10.1002/mrm.1910370228
M3 - Article
C2 - 9001156
AN - SCOPUS:0031012958
VL - 37
SP - 301
EP - 306
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
SN - 0740-3194
IS - 2
ER -