In vivo NMR imaging of tissue sodium in the intact cat before and after acute cerebral stroke.

S. K. Hilal, Andrew A Maudsley, H. E. Simon, W. H. Perman, J. Bonn, M. E. Mawad, A. J. Silver, S. R. Ganti, P. Sane, I. C. Chien

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Abstract

The first in vivo nuclear magnetic resonance (NMR) images of tissue sodium in the intact animal are presented. The distribution of sodium in the normal cat's head is described. An experimental stroke was surgically induced. Sodium NMR imaging showed a pronounced focal increase in cerebral sodium concentration 9 hr after ligation of the middle cerebral artery. The method appears to be very sensitive for early detection of infarction. The measured increase in the regional sodium NMR signal probably reflects both a true increase in concentration of brain sodium and an increased NMR visibility of the sodium nucleus in the region of the infarction.

Original languageEnglish
Pages (from-to)245-249
Number of pages5
JournalAmerican Journal of Neuroradiology
Volume4
Issue number3
StatePublished - May 1 1983
Externally publishedYes

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Cats
Magnetic Resonance Spectroscopy
Sodium
Stroke
Magnetic Resonance Imaging
Infarction
Middle Cerebral Artery
Ligation
Head
Brain

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Hilal, S. K., Maudsley, A. A., Simon, H. E., Perman, W. H., Bonn, J., Mawad, M. E., ... Chien, I. C. (1983). In vivo NMR imaging of tissue sodium in the intact cat before and after acute cerebral stroke. American Journal of Neuroradiology, 4(3), 245-249.

In vivo NMR imaging of tissue sodium in the intact cat before and after acute cerebral stroke. / Hilal, S. K.; Maudsley, Andrew A; Simon, H. E.; Perman, W. H.; Bonn, J.; Mawad, M. E.; Silver, A. J.; Ganti, S. R.; Sane, P.; Chien, I. C.

In: American Journal of Neuroradiology, Vol. 4, No. 3, 01.05.1983, p. 245-249.

Research output: Contribution to journalArticle

Hilal, SK, Maudsley, AA, Simon, HE, Perman, WH, Bonn, J, Mawad, ME, Silver, AJ, Ganti, SR, Sane, P & Chien, IC 1983, 'In vivo NMR imaging of tissue sodium in the intact cat before and after acute cerebral stroke.', American Journal of Neuroradiology, vol. 4, no. 3, pp. 245-249.
Hilal, S. K. ; Maudsley, Andrew A ; Simon, H. E. ; Perman, W. H. ; Bonn, J. ; Mawad, M. E. ; Silver, A. J. ; Ganti, S. R. ; Sane, P. ; Chien, I. C. / In vivo NMR imaging of tissue sodium in the intact cat before and after acute cerebral stroke. In: American Journal of Neuroradiology. 1983 ; Vol. 4, No. 3. pp. 245-249.
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