Abstract
We report the first clinical nuclear magnetic resonance (NMR) images of cerebral sodium distribution in normal volunteers and in patients with a variety of pathological lesions. We have used a 1.5 T NMR magnet system. When compared with proton distribution, sodium shows a greater variation in its concentration from tissue to tissue and from normal to pathological conditions. Image contrast calculated on the basis of sodium concentration is 7 to 18 times greater than that of proton spin density. Normal images emphasize the extracellular compartments. In the clinical studies, areas of recent or old cerebral infarction and tumors show a pronounced increase of sodium content (300-400%). Actual measurements of image density values indicate that there is probably a further accentuation of the contrast by the increased 'NMR visibility' of sodium in infarcted tissue. Sodium imaging may prove to be a more sensitive means for early detection of some brain disorders than other imaging methods.
| Original language | English |
|---|---|
| Pages (from-to) | 1-7 |
| Number of pages | 7 |
| Journal | Journal of Computer Assisted Tomography |
| Volume | 9 |
| Issue number | 1 |
| State | Published - Mar 20 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
In vivo NMR imaging of sodium-23 in the human head. / Hilal, S. K.; Maudsley, Andrew A; Ra, J. B.; Simon, H. E.; Roschmann, P.; Wittekoek, S.; Cho, Z. H.; Mun, S. K.
In: Journal of Computer Assisted Tomography, Vol. 9, No. 1, 20.03.1985, p. 1-7.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vivo NMR imaging of sodium-23 in the human head
AU - Hilal, S. K.
AU - Maudsley, Andrew A
AU - Ra, J. B.
AU - Simon, H. E.
AU - Roschmann, P.
AU - Wittekoek, S.
AU - Cho, Z. H.
AU - Mun, S. K.
PY - 1985/3/20
Y1 - 1985/3/20
N2 - We report the first clinical nuclear magnetic resonance (NMR) images of cerebral sodium distribution in normal volunteers and in patients with a variety of pathological lesions. We have used a 1.5 T NMR magnet system. When compared with proton distribution, sodium shows a greater variation in its concentration from tissue to tissue and from normal to pathological conditions. Image contrast calculated on the basis of sodium concentration is 7 to 18 times greater than that of proton spin density. Normal images emphasize the extracellular compartments. In the clinical studies, areas of recent or old cerebral infarction and tumors show a pronounced increase of sodium content (300-400%). Actual measurements of image density values indicate that there is probably a further accentuation of the contrast by the increased 'NMR visibility' of sodium in infarcted tissue. Sodium imaging may prove to be a more sensitive means for early detection of some brain disorders than other imaging methods.
AB - We report the first clinical nuclear magnetic resonance (NMR) images of cerebral sodium distribution in normal volunteers and in patients with a variety of pathological lesions. We have used a 1.5 T NMR magnet system. When compared with proton distribution, sodium shows a greater variation in its concentration from tissue to tissue and from normal to pathological conditions. Image contrast calculated on the basis of sodium concentration is 7 to 18 times greater than that of proton spin density. Normal images emphasize the extracellular compartments. In the clinical studies, areas of recent or old cerebral infarction and tumors show a pronounced increase of sodium content (300-400%). Actual measurements of image density values indicate that there is probably a further accentuation of the contrast by the increased 'NMR visibility' of sodium in infarcted tissue. Sodium imaging may prove to be a more sensitive means for early detection of some brain disorders than other imaging methods.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021962777&partnerID=8YFLogxK
M3 - Article
C2 - 3968256
AN - SCOPUS:0021962777
VL - 9
SP - 1
EP - 7
JO - Journal of Computer Assisted Tomography
JF - Journal of Computer Assisted Tomography
SN - 0363-8715
IS - 1
ER -