In vivo NMR imaging of sodium-23 in the human head

S. K. Hilal, Andrew A Maudsley, J. B. Ra, H. E. Simon, P. Roschmann, S. Wittekoek, Z. H. Cho, S. K. Mun

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

We report the first clinical nuclear magnetic resonance (NMR) images of cerebral sodium distribution in normal volunteers and in patients with a variety of pathological lesions. We have used a 1.5 T NMR magnet system. When compared with proton distribution, sodium shows a greater variation in its concentration from tissue to tissue and from normal to pathological conditions. Image contrast calculated on the basis of sodium concentration is 7 to 18 times greater than that of proton spin density. Normal images emphasize the extracellular compartments. In the clinical studies, areas of recent or old cerebral infarction and tumors show a pronounced increase of sodium content (300-400%). Actual measurements of image density values indicate that there is probably a further accentuation of the contrast by the increased 'NMR visibility' of sodium in infarcted tissue. Sodium imaging may prove to be a more sensitive means for early detection of some brain disorders than other imaging methods.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalJournal of Computer Assisted Tomography
Volume9
Issue number1
StatePublished - Mar 20 1985
Externally publishedYes

Fingerprint

Magnetic Resonance Spectroscopy
Sodium
Head
Magnetic Resonance Imaging
Protons
Magnets
Cerebral Infarction
Brain Diseases
Healthy Volunteers
Neoplasms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Hilal, S. K., Maudsley, A. A., Ra, J. B., Simon, H. E., Roschmann, P., Wittekoek, S., ... Mun, S. K. (1985). In vivo NMR imaging of sodium-23 in the human head. Journal of Computer Assisted Tomography, 9(1), 1-7.

In vivo NMR imaging of sodium-23 in the human head. / Hilal, S. K.; Maudsley, Andrew A; Ra, J. B.; Simon, H. E.; Roschmann, P.; Wittekoek, S.; Cho, Z. H.; Mun, S. K.

In: Journal of Computer Assisted Tomography, Vol. 9, No. 1, 20.03.1985, p. 1-7.

Research output: Contribution to journalArticle

Hilal, SK, Maudsley, AA, Ra, JB, Simon, HE, Roschmann, P, Wittekoek, S, Cho, ZH & Mun, SK 1985, 'In vivo NMR imaging of sodium-23 in the human head', Journal of Computer Assisted Tomography, vol. 9, no. 1, pp. 1-7.
Hilal SK, Maudsley AA, Ra JB, Simon HE, Roschmann P, Wittekoek S et al. In vivo NMR imaging of sodium-23 in the human head. Journal of Computer Assisted Tomography. 1985 Mar 20;9(1):1-7.
Hilal, S. K. ; Maudsley, Andrew A ; Ra, J. B. ; Simon, H. E. ; Roschmann, P. ; Wittekoek, S. ; Cho, Z. H. ; Mun, S. K. / In vivo NMR imaging of sodium-23 in the human head. In: Journal of Computer Assisted Tomography. 1985 ; Vol. 9, No. 1. pp. 1-7.
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