In vivo nmr imaging of sodium-23 in the human head

Sadek K. Hilal, Andrew A. Maudsley, J. B. Ra, Howard E. Simon, Peter Roschmann, Stefan Wittekoek, Z. H. Cho, S. K. Mun

Research output: Contribution to journalArticle

123 Scopus citations

Abstract

We report the first clinical nuclear magnetic resonance (NMR) images of cerebral sodium distribution in normal volunteers and in patients with a variety of pathological lesions. We have used a 1.5 T NMR magnet system. When compared with proton distribution, sodium shows a greater variation in its concentration from tissue to tissue and from normal to pathological conditions. Image contrast calculated on the basis of sodium concentration is 7 to 18 times greater than that of proton spin density. Normal images emphasize the extracellular compartments. In the clinical studies, areas of recent or old cerebral infarction and tumors show a pronounced increase of sodium content (300-400%). Actual measurements of image density values indicate that there is probably a further accentuation of the contrast by the increased 'NMR visibility' of sodium in infarcted tissue. Sodium imaging may prove to be a more sensitive means for early detection of some brain disorders than other imaging methods.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalJournal of computer assisted tomography
Volume9
Issue number1
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

Keywords

  • Nuclear magnetic resonance
  • Proton imaging
  • Sodium imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Hilal, S. K., Maudsley, A. A., Ra, J. B., Simon, H. E., Roschmann, P., Wittekoek, S., Cho, Z. H., & Mun, S. K. (1985). In vivo nmr imaging of sodium-23 in the human head. Journal of computer assisted tomography, 9(1), 1-7. https://doi.org/10.1097/00004728-198501000-00001