In vivo measurements of vascular oxygen tension in tumors using mri of a fluorinated blood substitute

Joel E. Fishman, Peter M. Joseph, Mark J. Carvlin, Mohamed Saadi-Elmandjra, Biswanath Mukherji, Henry A. Sloviter

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

The authors measured the level of blood oxygenation in vivo in a series of rats with implanted mammary adenocarcinoma. The technique used was 19F magnetic resonance imaging of a perfluorochemical blood substitute. The method is based on the effect of oxygen on the T1 relaxation time of the fluorochemical and allows the determination of mean vascular PO2 independent of the blood volume in this tissue. The PO2 levels in the liver, lung, and spleen also were determined and were consistent with previously reported results. When the rats breathed air, the tumor PO2 levels were somewhat lower than in the other organs and were in a range typical of venous blood. When the rat was given 100% oxygen to breathe, the tumor PO2 levels increased far less than the PO2 levels of the other organs. This may indicate a greatly diminished blood flow to this particular tumor.

Original languageEnglish (US)
Pages (from-to)65-71
Number of pages7
JournalInvestigative Radiology
Volume24
Issue number1
DOIs
StatePublished - Jan 1989
Externally publishedYes

Keywords

  • Fluorine
  • MRI
  • Oxygen tension
  • Perfusion
  • Tumor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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