In vivo measurement of the average refractive index of the human crystalline lens using optical coherence tomography

Carolina De Freitas, Marco Ruggeri, Fabrice Manns, Arthur Ho, Jean Marie Parel

Research output: Contribution to journalArticle

12 Scopus citations


We present a method for measuring the average group refractive index of the human crystalline lens in vivo using an optical coherence tomography (OCT) system which, allows full-length biometry of the eye. A series of OCT images of the eye including the anterior segment and retina were recorded during accommodation. Optical lengths of the anterior chamber, lens, and vitreous were measured dynamically along the central axis on the OCT images. The group refractive index of the crystalline lens along the central axis was determined using linear regression analysis of the intraocular optical length measurements. Measurements were acquired on three subjects of age 21, 24, and 35 years. The average group refractive index for the three subjects was, respectively, n = 1.41, 1.43, and 1.39 at 835 nm.

Original languageEnglish (US)
Pages (from-to)85-87
Number of pages3
JournalOptics Letters
Issue number2
StatePublished - Jan 15 2013


ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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