In vivo measurement of the attenuation coefficient of the sclera and ciliary muscle

GABRIELLE MONTERANO MESQUITA, DISHA PATEL, YU CHERNG CHANG, FLORENCE CABOT, MARCO RUGGERI, SONIA H. YOO, ARTHUR HO, JEAN MARIE A. PAREL, FABRICE MANNS

Research output: Contribution to journalArticlepeer-review

Abstract

We acquired 1325 nm OCT images of the sclera and ciliary muscle of human subjects. The attenuation coefficients of the sclera and ciliary muscle were determined from a curve fit of the average intensity profile of about 100 A-lines in a region of interest after correction for the effect of beam geometry, using a single scattering model. The average scleral attenuation coefficient was 4.13 ± 1.42mm-1 with an age-related decrease that was near the threshold for statistical significance (p = 0.053). The average ciliary muscle attenuation coefficient was 1.72 ± 0.88mm-1, but this value may be an underestimation due to contributions from multiple scattering. Overall, the results suggest that inter-individual variations in scleral attenuation contribute to variability in the quality of transscleral OCT images of the ciliary muscle and the outcome of transscleral laser therapies.

Original languageEnglish (US)
Pages (from-to)5089-5106
Number of pages18
JournalBiomedical Optics Express
Volume12
Issue number8
DOIs
StatePublished - Aug 1 2021

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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