In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction

Dara L. Kraitchman, Alan W. Heldman, Ergin Atalar, Luciano C. Amado, Bradley J. Martin, Mark F. Pittenger, Joshua M. Hare, Jeff W.M. Bulte

Research output: Contribution to journalArticle

610 Scopus citations

Abstract

Background - We investigated the potential of magnetic resonance imaging (MRI) to track magnetically labeled mesenchymal stem cells (MR-MSCs) in a swine myocardial infarction (MI) model. Methods and Results - Adult farm pigs (n=5) were subjected to closed-chest experimental MI. MR-MSCs (2.8 to 16×107 cells) were injected intramyocardially under x-ray fluoroscopy. MRIs were obtained on a 1.5T MR scanner to demonstrate the location of the MR-MSCs and were correlated with histology. Contrast-enhanced MRI demonstrated successful injection in the infarct and serial MSC tracking was demonstrated in two animals. Conclusion - MRI tracking of MSCs is feasible and represents a preferred method for studying the engraftment of MSCs in MI.

Original languageEnglish (US)
Pages (from-to)2290-2293
Number of pages4
JournalCirculation
Volume107
Issue number18
DOIs
StatePublished - May 13 2003

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Keywords

  • Cells
  • Contrast media
  • Magnetic resonance imaging
  • Myocardial infarction

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Kraitchman, D. L., Heldman, A. W., Atalar, E., Amado, L. C., Martin, B. J., Pittenger, M. F., Hare, J. M., & Bulte, J. W. M. (2003). In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction. Circulation, 107(18), 2290-2293. https://doi.org/10.1161/01.CIR.0000070931.62772.4E