In vivo immunopotentiating activity of thymopentin in aging humans: Increase of Il-2 production

Pier Luigi Meroni, Wilma Barcellini, Daniela Frasca, Chiara Sguotti, M. Orietta Borghi, Giovanni De Bartolo, Gino Doria, Carlo Zanussi

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

The effect of thymopentin (TP-5) treatment on lymphocyte immune functions has been investigated in immunocompromized aged subjects. TP-5 was able to improve the cutaneous delayed hypersensitivity (CDH) to recall antigens and the proliferative response to phytohemagglutinin (PHA), concanavalin A, and Pokeweed (PWM) as well as the PHA-induced interleukin-2 (Il-2) production. On the other hand, no detectable changes were induced by TP-5 treatment either on PWM-induced immunoglobulin synthesis or on lymphocyte subsets identified by monoclonal antibodies. Our results suggest that the enhancement of Il-2 synthesis might be a crucial mechanism of the immunopharmacological action of TP-5 in aging humans.

Original languageEnglish (US)
Pages (from-to)151-159
Number of pages9
JournalClinical Immunology and Immunopathology
Volume42
Issue number2
DOIs
StatePublished - Feb 1987
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

Cite this

Meroni, P. L., Barcellini, W., Frasca, D., Sguotti, C., Borghi, M. O., De Bartolo, G., Doria, G., & Zanussi, C. (1987). In vivo immunopotentiating activity of thymopentin in aging humans: Increase of Il-2 production. Clinical Immunology and Immunopathology, 42(2), 151-159. https://doi.org/10.1016/0090-1229(87)90002-X