In vivo immunopotentiating activity of thymopentin in aging humans: Increase of Il-2 production

Pier Luigi Meroni, Wilma Barcellini, Daniela Frasca, Chiara Sguotti, M. Orietta Borghi, Giovanni De Bartolo, Gino Doria, Carlo Zanussi

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The effect of thymopentin (TP-5) treatment on lymphocyte immune functions has been investigated in immunocompromized aged subjects. TP-5 was able to improve the cutaneous delayed hypersensitivity (CDH) to recall antigens and the proliferative response to phytohemagglutinin (PHA), concanavalin A, and Pokeweed (PWM) as well as the PHA-induced interleukin-2 (Il-2) production. On the other hand, no detectable changes were induced by TP-5 treatment either on PWM-induced immunoglobulin synthesis or on lymphocyte subsets identified by monoclonal antibodies. Our results suggest that the enhancement of Il-2 synthesis might be a crucial mechanism of the immunopharmacological action of TP-5 in aging humans.

Original languageEnglish
Pages (from-to)151-159
Number of pages9
JournalClinical Immunology and Immunopathology
Volume42
Issue number2
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

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Thymopentin
Interleukin-2
Phytohemagglutinins
Phytolacca americana
Lymphocyte Subsets
Delayed Hypersensitivity
Concanavalin A
Immunoglobulins
Monoclonal Antibodies
Lymphocytes
Antigens
Skin

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

In vivo immunopotentiating activity of thymopentin in aging humans : Increase of Il-2 production. / Meroni, Pier Luigi; Barcellini, Wilma; Frasca, Daniela; Sguotti, Chiara; Borghi, M. Orietta; De Bartolo, Giovanni; Doria, Gino; Zanussi, Carlo.

In: Clinical Immunology and Immunopathology, Vol. 42, No. 2, 01.01.1987, p. 151-159.

Research output: Contribution to journalArticle

Meroni, PL, Barcellini, W, Frasca, D, Sguotti, C, Borghi, MO, De Bartolo, G, Doria, G & Zanussi, C 1987, 'In vivo immunopotentiating activity of thymopentin in aging humans: Increase of Il-2 production', Clinical Immunology and Immunopathology, vol. 42, no. 2, pp. 151-159. https://doi.org/10.1016/0090-1229(87)90002-X
Meroni, Pier Luigi ; Barcellini, Wilma ; Frasca, Daniela ; Sguotti, Chiara ; Borghi, M. Orietta ; De Bartolo, Giovanni ; Doria, Gino ; Zanussi, Carlo. / In vivo immunopotentiating activity of thymopentin in aging humans : Increase of Il-2 production. In: Clinical Immunology and Immunopathology. 1987 ; Vol. 42, No. 2. pp. 151-159.
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