In vivo effects of recombinant human and murine interleukin-1α (IL-1α) on murine hematopoiesis

C. S. Johnson, P. G. Braunschweiger, P. Furmanski

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Interleukin-1α (IL-1α) has profound effects on hematopoiesis that could be exploited therapeutically. The cytokine potentiates immature myeloid and erythroid progenitor cells and suppresses late-stage erythropoiesis. To evaluate the species specificity of IL-1α's activities, we compared the dose-related in vivo effects of recombinant murine IL-1α (MuIL-1α) with recombinant human IL-1α (HuIL-1α) on mouse hematopoietic precursor cells. Normal mice were treated with a single i.p. injection of either HuIL-1α or MuIL-α at various doses and assayed 48 hours later. MuIL-1α induced a significantly greater suppression of mature erythroid progenitors (CFU-E) than an equivalent dose of HuIL-1α. Like-wise, the immature erythroid (BFU-E) as well as the mature macrophage (CFU-M) progenitors were stimulated to a significantly greater extent with MuIL-1α than with HuIL-1α. These results demonstrate that isologous system should be utilized to optimally evaluate the in vivo use of IL-1α for potentiating hematopoiesis.

Original languageEnglish (US)
Pages (from-to)93-96
Number of pages4
JournalIn Vivo
Volume4
Issue number2
StatePublished - 1990

Keywords

  • erythropoiesis
  • hematopoiesis
  • interleukin-1α
  • species-specificity

ASJC Scopus subject areas

  • Medicine(all)

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