Interleukin-1α (IL-1α) has profound effects on hematopoiesis that could be exploited therapeutically. The cytokine potentiates immature myeloid and erythroid progenitor cells and suppresses late-stage erythropoiesis. To evaluate the species specificity of IL-1α's activities, we compared the dose-related in vivo effects of recombinant murine IL-1α (MuIL-1α) with recombinant human IL-1α (HuIL-1α) on mouse hematopoietic precursor cells. Normal mice were treated with a single i.p. injection of either HuIL-1α or MuIL-α at various doses and assayed 48 hours later. MuIL-1α induced a significantly greater suppression of mature erythroid progenitors (CFU-E) than an equivalent dose of HuIL-1α. Like-wise, the immature erythroid (BFU-E) as well as the mature macrophage (CFU-M) progenitors were stimulated to a significantly greater extent with MuIL-1α than with HuIL-1α. These results demonstrate that isologous system should be utilized to optimally evaluate the in vivo use of IL-1α for potentiating hematopoiesis.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Jan 1 1990|
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