In vivo effects of a single infusion of theophylline on human peripheral blood lymphocytes

R. Pardi, M. R. Zocchi, E. Ferrero, G. F. Ciboddo, Luca A Inverardi, C. Rugarli

Research output: Contribution to journalArticle

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Abstract

It has recently been proposed that theophylline activates T suppressor systems in vivo and this evidence is further supported by the ability of the drug to attenuate the allograft rejection in humans and in experimental animals. In this study the acute effects of aminophylline on human peripheral blood lymphocyte (PBL) mitogeic responses have been investigated. PBL from healthy young volunteers who received intravenous aminophylline (5 mg/kg i.v. over 20 min) showed an increased proliferative response to phytohaemagglutinin. This was correlated with an augmented OKT4/OKT8 ratio, due to an absolute increase in the OKT4+ subset as well as a decrease in OKT8+ cells. Furthermore, following in vivo aminophylline we observed a significant rise in lymphocyte cAMP levels. These data, together with studies from other laboratories, suggest that the dosages and duration of treatment may influence greatly the theophylline-induced modulation of immune functions.

Original languageEnglish
Pages (from-to)722-728
Number of pages7
JournalClinical and Experimental Immunology
Volume57
Issue number3
StatePublished - Oct 11 1984
Externally publishedYes

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Aminophylline
Theophylline
Lymphocytes
Phytohemagglutinins
Allografts
Healthy Volunteers
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Immunology

Cite this

Pardi, R., Zocchi, M. R., Ferrero, E., Ciboddo, G. F., Inverardi, L. A., & Rugarli, C. (1984). In vivo effects of a single infusion of theophylline on human peripheral blood lymphocytes. Clinical and Experimental Immunology, 57(3), 722-728.

In vivo effects of a single infusion of theophylline on human peripheral blood lymphocytes. / Pardi, R.; Zocchi, M. R.; Ferrero, E.; Ciboddo, G. F.; Inverardi, Luca A; Rugarli, C.

In: Clinical and Experimental Immunology, Vol. 57, No. 3, 11.10.1984, p. 722-728.

Research output: Contribution to journalArticle

Pardi, R, Zocchi, MR, Ferrero, E, Ciboddo, GF, Inverardi, LA & Rugarli, C 1984, 'In vivo effects of a single infusion of theophylline on human peripheral blood lymphocytes', Clinical and Experimental Immunology, vol. 57, no. 3, pp. 722-728.
Pardi R, Zocchi MR, Ferrero E, Ciboddo GF, Inverardi LA, Rugarli C. In vivo effects of a single infusion of theophylline on human peripheral blood lymphocytes. Clinical and Experimental Immunology. 1984 Oct 11;57(3):722-728.
Pardi, R. ; Zocchi, M. R. ; Ferrero, E. ; Ciboddo, G. F. ; Inverardi, Luca A ; Rugarli, C. / In vivo effects of a single infusion of theophylline on human peripheral blood lymphocytes. In: Clinical and Experimental Immunology. 1984 ; Vol. 57, No. 3. pp. 722-728.
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