In vivo diagnosis of melanoma and nonmelanoma skin cancer using oblique incidence diffuse reflectance spectrometry

Alejandro Garcia-Uribe, Jun Zou, Madeleine Duvic, Jeong Hee Cho, Victor G. Prieto, Lihong V. Wang

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Early detection and treatment of skin cancer can significantly improve patient outcome. However, present standards for diagnosis require biopsy and histopathologic examinations that are relatively invasive, expensive, and difficult for patients with many early-stage lesions. Here, we show an oblique incidence diffuse reflectance spectroscopic (OIDRS) system that can be used for rapid skin cancer detection in vivo. This system was tested under clinical conditions by obtaining spectra from pigmented and nonpigmented skin lesions, including melanomas, differently staged dysplastic nevi, and common nevi that were validated by standard pathohistologic criteria. For diagnosis of pigmented melanoma, the data obtained achieved 90% sensitivity and specificity for a blinded test set. In a second analysis, we showed that this spectroscopy system can also differentiate nonpigmented basal cell or squamous cell carcinomas from noncancerous skin abnormalities, such as actinic keratoses and seborrheic keratoses, achieving 92% sensitivity and specificity. Taken together, our findings establish how OIDRS can be used to more rapidly and easily diagnose skin cancer in an accurate and automated manner in the clinic.

Original languageEnglish (US)
Pages (from-to)2738-2745
Number of pages8
JournalCancer Research
Volume72
Issue number11
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

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Skin Neoplasms
Melanoma
Spectrum Analysis
Incidence
Skin Abnormalities
Seborrheic Keratosis
Dysplastic Nevus Syndrome
Actinic Keratosis
Sensitivity and Specificity
Nevus
Squamous Cell Carcinoma
Biopsy
Skin
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

In vivo diagnosis of melanoma and nonmelanoma skin cancer using oblique incidence diffuse reflectance spectrometry. / Garcia-Uribe, Alejandro; Zou, Jun; Duvic, Madeleine; Cho, Jeong Hee; Prieto, Victor G.; Wang, Lihong V.

In: Cancer Research, Vol. 72, No. 11, 01.06.2012, p. 2738-2745.

Research output: Contribution to journalArticle

Garcia-Uribe, Alejandro ; Zou, Jun ; Duvic, Madeleine ; Cho, Jeong Hee ; Prieto, Victor G. ; Wang, Lihong V. / In vivo diagnosis of melanoma and nonmelanoma skin cancer using oblique incidence diffuse reflectance spectrometry. In: Cancer Research. 2012 ; Vol. 72, No. 11. pp. 2738-2745.
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