Abstract
According to the Epilepsy Foundation, about 45,000 children under the age of 15 develop epilepsy each year. One of the long-standing challenges in the field of pediatric epilepsy research is to differentiate between normal and epileptic brain areas. This problem is especially important for children with intractable epilepsy, because surgical intervention must be used to alleviate their epileptic symptoms. Optical spectroscopy may be used to assess the pathophysiological characteristics of the epileptic brain tissue intraoperatively in a non-destructive manner, which, in turn, allows surgeons to plan an epilepsy surgery. Herein, the study is focused on demonstrating the feasibility of using time-dependent, diffuse reflectance spectroscopy specifically to detect pathophysiological characteristics associated with epileptic brain tissue. In a pediatric patient undergoing epilepsy surgery, time-dependent, diffuse reflectance spectra were measured from the epileptic cortex and the surrounding tissue using a fiber-optic spectroscopy system. The system was designed to acquire diffuse reflectance spectra from 300 - 1100 nm at a maximum acquisition rate of 33 Hz. Spectral and temporal variations in the acquired spectral sequences were compared to the corresponding electrocorticographic results, and thosevariations unique to the epileptic cortex were identified using statistical methods. Furthermore, these spectral variations were related to the physiological and morphological characteristics of the brain tissue. The preliminary results obtained from this in vivo study demonstrate the feasibility of differentiating epileptic cortex tissue from normal tissue using time-dependent, diffuse reflectance data.
| Original language | English |
|---|---|
| Title of host publication | IFMBE Proceedings |
| Pages | 105-108 |
| Number of pages | 4 |
| Volume | 32 IFMBE |
| DOIs | |
| State | Published - Nov 8 2010 |
| Event | 26th Southern Biomedical Engineering Conference, SBEC 2010 - College Park, MD, United States Duration: Apr 30 2010 → May 2 2010 |
Other
| Other | 26th Southern Biomedical Engineering Conference, SBEC 2010 |
|---|---|
| Country | United States |
| City | College Park, MD |
| Period | 4/30/10 → 5/2/10 |
Fingerprint
Keywords
- Correlation
- Diffuse Reflectance
- Epilepsy
- Optical Spectroscopy
- Time dependent
ASJC Scopus subject areas
- Biomedical Engineering
- Bioengineering
Cite this
In vivo characterization of epileptic tissue with time-dependent, diffuse reflectance spectroscopy. / Yadav, Nitin; Oh, Sanghoon; Bhatia, Sanjeev; Ragheb, John; Jayakar, Prasanna; Duchowny, Michael; Lin, Wei Chiang.
IFMBE Proceedings. Vol. 32 IFMBE 2010. p. 105-108.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - In vivo characterization of epileptic tissue with time-dependent, diffuse reflectance spectroscopy
AU - Yadav, Nitin
AU - Oh, Sanghoon
AU - Bhatia, Sanjeev
AU - Ragheb, John
AU - Jayakar, Prasanna
AU - Duchowny, Michael
AU - Lin, Wei Chiang
PY - 2010/11/8
Y1 - 2010/11/8
N2 - According to the Epilepsy Foundation, about 45,000 children under the age of 15 develop epilepsy each year. One of the long-standing challenges in the field of pediatric epilepsy research is to differentiate between normal and epileptic brain areas. This problem is especially important for children with intractable epilepsy, because surgical intervention must be used to alleviate their epileptic symptoms. Optical spectroscopy may be used to assess the pathophysiological characteristics of the epileptic brain tissue intraoperatively in a non-destructive manner, which, in turn, allows surgeons to plan an epilepsy surgery. Herein, the study is focused on demonstrating the feasibility of using time-dependent, diffuse reflectance spectroscopy specifically to detect pathophysiological characteristics associated with epileptic brain tissue. In a pediatric patient undergoing epilepsy surgery, time-dependent, diffuse reflectance spectra were measured from the epileptic cortex and the surrounding tissue using a fiber-optic spectroscopy system. The system was designed to acquire diffuse reflectance spectra from 300 - 1100 nm at a maximum acquisition rate of 33 Hz. Spectral and temporal variations in the acquired spectral sequences were compared to the corresponding electrocorticographic results, and thosevariations unique to the epileptic cortex were identified using statistical methods. Furthermore, these spectral variations were related to the physiological and morphological characteristics of the brain tissue. The preliminary results obtained from this in vivo study demonstrate the feasibility of differentiating epileptic cortex tissue from normal tissue using time-dependent, diffuse reflectance data.
AB - According to the Epilepsy Foundation, about 45,000 children under the age of 15 develop epilepsy each year. One of the long-standing challenges in the field of pediatric epilepsy research is to differentiate between normal and epileptic brain areas. This problem is especially important for children with intractable epilepsy, because surgical intervention must be used to alleviate their epileptic symptoms. Optical spectroscopy may be used to assess the pathophysiological characteristics of the epileptic brain tissue intraoperatively in a non-destructive manner, which, in turn, allows surgeons to plan an epilepsy surgery. Herein, the study is focused on demonstrating the feasibility of using time-dependent, diffuse reflectance spectroscopy specifically to detect pathophysiological characteristics associated with epileptic brain tissue. In a pediatric patient undergoing epilepsy surgery, time-dependent, diffuse reflectance spectra were measured from the epileptic cortex and the surrounding tissue using a fiber-optic spectroscopy system. The system was designed to acquire diffuse reflectance spectra from 300 - 1100 nm at a maximum acquisition rate of 33 Hz. Spectral and temporal variations in the acquired spectral sequences were compared to the corresponding electrocorticographic results, and thosevariations unique to the epileptic cortex were identified using statistical methods. Furthermore, these spectral variations were related to the physiological and morphological characteristics of the brain tissue. The preliminary results obtained from this in vivo study demonstrate the feasibility of differentiating epileptic cortex tissue from normal tissue using time-dependent, diffuse reflectance data.
KW - Correlation
KW - Diffuse Reflectance
KW - Epilepsy
KW - Optical Spectroscopy
KW - Time dependent
UR - http://www.scopus.com/inward/record.url?scp=78049406097&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78049406097&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-14998-6_28
DO - 10.1007/978-3-642-14998-6_28
M3 - Conference contribution
AN - SCOPUS:78049406097
SN - 9783642149979
VL - 32 IFMBE
SP - 105
EP - 108
BT - IFMBE Proceedings
ER -