In vivo characterization of epileptic tissue with time-dependent, diffuse reflectance spectroscopy

Nitin Yadav, Sanghoon Oh, Sanjeev Bhatia, John Ragheb, Prasanna Jayakar, Michael Duchowny, Wei Chiang Lin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

According to the Epilepsy Foundation, about 45,000 children under the age of 15 develop epilepsy each year. One of the long-standing challenges in the field of pediatric epilepsy research is to differentiate between normal and epileptic brain areas. This problem is especially important for children with intractable epilepsy, because surgical intervention must be used to alleviate their epileptic symptoms. Optical spectroscopy may be used to assess the pathophysiological characteristics of the epileptic brain tissue intraoperatively in a non-destructive manner, which, in turn, allows surgeons to plan an epilepsy surgery. Herein, the study is focused on demonstrating the feasibility of using time-dependent, diffuse reflectance spectroscopy specifically to detect pathophysiological characteristics associated with epileptic brain tissue. In a pediatric patient undergoing epilepsy surgery, time-dependent, diffuse reflectance spectra were measured from the epileptic cortex and the surrounding tissue using a fiber-optic spectroscopy system. The system was designed to acquire diffuse reflectance spectra from 300 - 1100 nm at a maximum acquisition rate of 33 Hz. Spectral and temporal variations in the acquired spectral sequences were compared to the corresponding electrocorticographic results, and thosevariations unique to the epileptic cortex were identified using statistical methods. Furthermore, these spectral variations were related to the physiological and morphological characteristics of the brain tissue. The preliminary results obtained from this in vivo study demonstrate the feasibility of differentiating epileptic cortex tissue from normal tissue using time-dependent, diffuse reflectance data.

Original languageEnglish
Title of host publicationIFMBE Proceedings
Pages105-108
Number of pages4
Volume32 IFMBE
DOIs
StatePublished - Nov 8 2010
Event26th Southern Biomedical Engineering Conference, SBEC 2010 - College Park, MD, United States
Duration: Apr 30 2010May 2 2010

Other

Other26th Southern Biomedical Engineering Conference, SBEC 2010
CountryUnited States
CityCollege Park, MD
Period4/30/105/2/10

Fingerprint

Spectroscopy
Tissue
Brain
Pediatrics
Surgery
Fiber optics
Statistical methods

Keywords

  • Correlation
  • Diffuse Reflectance
  • Epilepsy
  • Optical Spectroscopy
  • Time dependent

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

Cite this

Yadav, N., Oh, S., Bhatia, S., Ragheb, J., Jayakar, P., Duchowny, M., & Lin, W. C. (2010). In vivo characterization of epileptic tissue with time-dependent, diffuse reflectance spectroscopy. In IFMBE Proceedings (Vol. 32 IFMBE, pp. 105-108) https://doi.org/10.1007/978-3-642-14998-6_28

In vivo characterization of epileptic tissue with time-dependent, diffuse reflectance spectroscopy. / Yadav, Nitin; Oh, Sanghoon; Bhatia, Sanjeev; Ragheb, John; Jayakar, Prasanna; Duchowny, Michael; Lin, Wei Chiang.

IFMBE Proceedings. Vol. 32 IFMBE 2010. p. 105-108.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yadav, N, Oh, S, Bhatia, S, Ragheb, J, Jayakar, P, Duchowny, M & Lin, WC 2010, In vivo characterization of epileptic tissue with time-dependent, diffuse reflectance spectroscopy. in IFMBE Proceedings. vol. 32 IFMBE, pp. 105-108, 26th Southern Biomedical Engineering Conference, SBEC 2010, College Park, MD, United States, 4/30/10. https://doi.org/10.1007/978-3-642-14998-6_28
Yadav N, Oh S, Bhatia S, Ragheb J, Jayakar P, Duchowny M et al. In vivo characterization of epileptic tissue with time-dependent, diffuse reflectance spectroscopy. In IFMBE Proceedings. Vol. 32 IFMBE. 2010. p. 105-108 https://doi.org/10.1007/978-3-642-14998-6_28
Yadav, Nitin ; Oh, Sanghoon ; Bhatia, Sanjeev ; Ragheb, John ; Jayakar, Prasanna ; Duchowny, Michael ; Lin, Wei Chiang. / In vivo characterization of epileptic tissue with time-dependent, diffuse reflectance spectroscopy. IFMBE Proceedings. Vol. 32 IFMBE 2010. pp. 105-108
@inproceedings{e159dca078ba4ceda083c46a60ba1785,
title = "In vivo characterization of epileptic tissue with time-dependent, diffuse reflectance spectroscopy",
abstract = "According to the Epilepsy Foundation, about 45,000 children under the age of 15 develop epilepsy each year. One of the long-standing challenges in the field of pediatric epilepsy research is to differentiate between normal and epileptic brain areas. This problem is especially important for children with intractable epilepsy, because surgical intervention must be used to alleviate their epileptic symptoms. Optical spectroscopy may be used to assess the pathophysiological characteristics of the epileptic brain tissue intraoperatively in a non-destructive manner, which, in turn, allows surgeons to plan an epilepsy surgery. Herein, the study is focused on demonstrating the feasibility of using time-dependent, diffuse reflectance spectroscopy specifically to detect pathophysiological characteristics associated with epileptic brain tissue. In a pediatric patient undergoing epilepsy surgery, time-dependent, diffuse reflectance spectra were measured from the epileptic cortex and the surrounding tissue using a fiber-optic spectroscopy system. The system was designed to acquire diffuse reflectance spectra from 300 - 1100 nm at a maximum acquisition rate of 33 Hz. Spectral and temporal variations in the acquired spectral sequences were compared to the corresponding electrocorticographic results, and thosevariations unique to the epileptic cortex were identified using statistical methods. Furthermore, these spectral variations were related to the physiological and morphological characteristics of the brain tissue. The preliminary results obtained from this in vivo study demonstrate the feasibility of differentiating epileptic cortex tissue from normal tissue using time-dependent, diffuse reflectance data.",
keywords = "Correlation, Diffuse Reflectance, Epilepsy, Optical Spectroscopy, Time dependent",
author = "Nitin Yadav and Sanghoon Oh and Sanjeev Bhatia and John Ragheb and Prasanna Jayakar and Michael Duchowny and Lin, {Wei Chiang}",
year = "2010",
month = "11",
day = "8",
doi = "10.1007/978-3-642-14998-6_28",
language = "English",
isbn = "9783642149979",
volume = "32 IFMBE",
pages = "105--108",
booktitle = "IFMBE Proceedings",

}

TY - GEN

T1 - In vivo characterization of epileptic tissue with time-dependent, diffuse reflectance spectroscopy

AU - Yadav, Nitin

AU - Oh, Sanghoon

AU - Bhatia, Sanjeev

AU - Ragheb, John

AU - Jayakar, Prasanna

AU - Duchowny, Michael

AU - Lin, Wei Chiang

PY - 2010/11/8

Y1 - 2010/11/8

N2 - According to the Epilepsy Foundation, about 45,000 children under the age of 15 develop epilepsy each year. One of the long-standing challenges in the field of pediatric epilepsy research is to differentiate between normal and epileptic brain areas. This problem is especially important for children with intractable epilepsy, because surgical intervention must be used to alleviate their epileptic symptoms. Optical spectroscopy may be used to assess the pathophysiological characteristics of the epileptic brain tissue intraoperatively in a non-destructive manner, which, in turn, allows surgeons to plan an epilepsy surgery. Herein, the study is focused on demonstrating the feasibility of using time-dependent, diffuse reflectance spectroscopy specifically to detect pathophysiological characteristics associated with epileptic brain tissue. In a pediatric patient undergoing epilepsy surgery, time-dependent, diffuse reflectance spectra were measured from the epileptic cortex and the surrounding tissue using a fiber-optic spectroscopy system. The system was designed to acquire diffuse reflectance spectra from 300 - 1100 nm at a maximum acquisition rate of 33 Hz. Spectral and temporal variations in the acquired spectral sequences were compared to the corresponding electrocorticographic results, and thosevariations unique to the epileptic cortex were identified using statistical methods. Furthermore, these spectral variations were related to the physiological and morphological characteristics of the brain tissue. The preliminary results obtained from this in vivo study demonstrate the feasibility of differentiating epileptic cortex tissue from normal tissue using time-dependent, diffuse reflectance data.

AB - According to the Epilepsy Foundation, about 45,000 children under the age of 15 develop epilepsy each year. One of the long-standing challenges in the field of pediatric epilepsy research is to differentiate between normal and epileptic brain areas. This problem is especially important for children with intractable epilepsy, because surgical intervention must be used to alleviate their epileptic symptoms. Optical spectroscopy may be used to assess the pathophysiological characteristics of the epileptic brain tissue intraoperatively in a non-destructive manner, which, in turn, allows surgeons to plan an epilepsy surgery. Herein, the study is focused on demonstrating the feasibility of using time-dependent, diffuse reflectance spectroscopy specifically to detect pathophysiological characteristics associated with epileptic brain tissue. In a pediatric patient undergoing epilepsy surgery, time-dependent, diffuse reflectance spectra were measured from the epileptic cortex and the surrounding tissue using a fiber-optic spectroscopy system. The system was designed to acquire diffuse reflectance spectra from 300 - 1100 nm at a maximum acquisition rate of 33 Hz. Spectral and temporal variations in the acquired spectral sequences were compared to the corresponding electrocorticographic results, and thosevariations unique to the epileptic cortex were identified using statistical methods. Furthermore, these spectral variations were related to the physiological and morphological characteristics of the brain tissue. The preliminary results obtained from this in vivo study demonstrate the feasibility of differentiating epileptic cortex tissue from normal tissue using time-dependent, diffuse reflectance data.

KW - Correlation

KW - Diffuse Reflectance

KW - Epilepsy

KW - Optical Spectroscopy

KW - Time dependent

UR - http://www.scopus.com/inward/record.url?scp=78049406097&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78049406097&partnerID=8YFLogxK

U2 - 10.1007/978-3-642-14998-6_28

DO - 10.1007/978-3-642-14998-6_28

M3 - Conference contribution

SN - 9783642149979

VL - 32 IFMBE

SP - 105

EP - 108

BT - IFMBE Proceedings

ER -