In vivo assessment of oxygen consumption via deuterium magnetic resonance

Gheorghe D. Mateescu, Allen Ye, Chris A. Flask, Bernadette Erokwu, Jeffrey L. Duerk

Research output: Chapter in Book/Report/Conference proceedingConference contribution

11 Scopus citations

Abstract

We present a novel approach to simultaneously measure, in vivo, noninvasively, glucose and oxygen consumption via Deuterium Magnetic Resonance (DMR). Mice are administered deuteriated glucose by intravenous injection. The rate of formation of nascent (deuteriated) mitochondrial water is then measured via DMR. The rate of glucose metabolism and oxygen utilization is assessed by tracking their separate peaks in DMR spectra during dynamic scanning. Further studies will aim to validate these results by comparison with in vivo 17O-MRI (mitochondrial function), 13C-MRI and 19FDG-PET (glucose metabolism) and ex vivo 1H- and 2H-MR, as well as mass spectrometry.1

Original languageEnglish (US)
Title of host publicationOxygen Transport to Tissue XXXII
PublisherSpringer New York LLC
Pages193-199
Number of pages7
ISBN (Print)9781441977557
DOIs
StatePublished - 2011
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume701
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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