In vitro testing for the risk of arachnoiditis from myelographic contrast media

Herman S. Cheung; Johan G. Johansen; Victor M. Haughton; Thomas R. Nichols

doi:10.1097/00004424-198508000-00006

In vitro testing for the risk of arachnoiditis from myelographic contrast media

Herman S. Cheung, Johan G. Johansen, Victor M. Haughton, Thomas R. Nichols

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The risk of arachnoiditis from aqueous myelographic contrast media has been assayed reliably only in experimental animals. The effect of contrast media on protein and collagen production by fibroblasts in vitro was studied. Iocarmate, metrizamide, and iopamidol added to the culture medium caused cells to produce more protein and collagen. The degree to which the contrast medium stimulated collagen production correlated with the risk of arachnoiditis from the intrathecal use of the contrast medium. In vitro testing appears to be an effective assay for arachnoiditis

Original language	English (US)
Pages (from-to)	472-475
Number of pages	4
Journal	Investigative Radiology
Volume	20
Issue number	5
DOIs	https://doi.org/10.1097/00004424-198508000-00006
State	Published - Aug 1985
Externally published	Yes

Keywords

Arachnoiditis
Myelographic contrast media

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1097/00004424-198508000-00006

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title = "In vitro testing for the risk of arachnoiditis from myelographic contrast media",

abstract = "The risk of arachnoiditis from aqueous myelographic contrast media has been assayed reliably only in experimental animals. The effect of contrast media on protein and collagen production by fibroblasts in vitro was studied. Iocarmate, metrizamide, and iopamidol added to the culture medium caused cells to produce more protein and collagen. The degree to which the contrast medium stimulated collagen production correlated with the risk of arachnoiditis from the intrathecal use of the contrast medium. In vitro testing appears to be an effective assay for arachnoiditis",

keywords = "Arachnoiditis, Myelographic contrast media",

author = "Cheung, {Herman S.} and Johansen, {Johan G.} and Haughton, {Victor M.} and Nichols, {Thomas R.}",

year = "1985",

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AU - Cheung, Herman S.

AU - Johansen, Johan G.

AU - Haughton, Victor M.

AU - Nichols, Thomas R.

PY - 1985/8

Y1 - 1985/8

N2 - The risk of arachnoiditis from aqueous myelographic contrast media has been assayed reliably only in experimental animals. The effect of contrast media on protein and collagen production by fibroblasts in vitro was studied. Iocarmate, metrizamide, and iopamidol added to the culture medium caused cells to produce more protein and collagen. The degree to which the contrast medium stimulated collagen production correlated with the risk of arachnoiditis from the intrathecal use of the contrast medium. In vitro testing appears to be an effective assay for arachnoiditis

AB - The risk of arachnoiditis from aqueous myelographic contrast media has been assayed reliably only in experimental animals. The effect of contrast media on protein and collagen production by fibroblasts in vitro was studied. Iocarmate, metrizamide, and iopamidol added to the culture medium caused cells to produce more protein and collagen. The degree to which the contrast medium stimulated collagen production correlated with the risk of arachnoiditis from the intrathecal use of the contrast medium. In vitro testing appears to be an effective assay for arachnoiditis

KW - Arachnoiditis

KW - Myelographic contrast media

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JO - Investigative Radiology

JF - Investigative Radiology

SN - 0020-9996

IS - 5

ER -

In vitro testing for the risk of arachnoiditis from myelographic contrast media

Abstract

Keywords

ASJC Scopus subject areas

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