In vitro testing for the risk of arachnoiditis from myelographic contrast media

Herman S. Cheung, Johan G. Johansen, Victor M. Haughton, Thomas R. Nichols

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The risk of arachnoiditis from aqueous myelographic contrast media has been assayed reliably only in experimental animals. The effect of contrast media on protein and collagen production by fibroblasts in vitro was studied. Iocarmate, metrizamide, and iopamidol added to the culture medium caused cells to produce more protein and collagen. The degree to which the contrast medium stimulated collagen production correlated with the risk of arachnoiditis from the intrathecal use of the contrast medium. In vitro testing appears to be an effective assay for arachnoiditis

Original languageEnglish (US)
Pages (from-to)472-475
Number of pages4
JournalInvestigative Radiology
Volume20
Issue number5
DOIs
StatePublished - Aug 1985

Keywords

  • Arachnoiditis
  • Myelographic contrast media

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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