In vitro models of axon regeneration

Research output: Contribution to journalArticle

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Abstract

A variety of in vitro models has been developed to understand the mechanisms underlying the regenerative failure of central nervous system (CNS) axons, and to guide pre-clinical development of regeneration-promoting therapeutics. These range from single-cell based assays that typically focus on molecular mechanisms to organotypic assays aimed at recapitulating in vivo behavior. By utilizing a combination of models, researchers can balance the speed, convenience, and mechanistic resolution of simpler models with the biological relevance of more complex models. This review will discuss a number of the models that have been used to build our understanding of molecular mechanisms of CNS axon regeneration.

Original languageEnglish (US)
JournalExperimental Neurology
DOIs
StateAccepted/In press - Dec 4 2015

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Keywords

  • Axon regeneration
  • Cell based assays
  • High content screening
  • In vitro models
  • Neurite outgrowth
  • Organotypic assays

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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