In vitro models of axon regeneration

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

A variety of in vitro models have been developed to understand the mechanisms underlying the regenerative failure of central nervous system (CNS) axons, and to guide pre-clinical development of regeneration-promoting therapeutics. These range from single-cell based assays that typically focus on molecular mechanisms to organotypic assays that aim to recapitulate in vivo behavior. By utilizing a combination of models, researchers can balance the speed, convenience, and mechanistic resolution of simpler models with the biological relevance of more complex models. This review will discuss a number of models that have been used to build our understanding of the molecular mechanisms of CNS axon regeneration.

Original languageEnglish (US)
Pages (from-to)423-434
Number of pages12
JournalExperimental neurology
Volume287
DOIs
StatePublished - Jan 1 2017

Keywords

  • Axon regeneration
  • Cell based assays
  • High content screening
  • In vitro models
  • Neurite outgrowth
  • Organotypic assays

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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