Abstract
Hepatitis C virus (HCV) is a major cause of chronic liver diseases including steatosis, cirrhosis and hepatocellular carcinoma. Currently, there is no vaccine available for prevention of HCV infection due to high degree of strain variation. The current treatment of care, Pegylated interferon α in combination with ribavirin is costly, has significant side effects and fails to cure about half of all infections. The development of in-vitro models such as HCV infection system, HCV sub-genomic replicon, HCV producing pseudoparticles (HCVpp) and infectious HCV virion provide an important tool to develop new antiviral drugs of different targets against HCV. These models also play an important role to study virus lifecycle such as virus entry, endocytosis, replication, release and HCV induced pathogenesis. This review summarizes the most important in-vitro models currently used to study future HCV research as well as drug design.
| Original language | English |
|---|---|
| Article number | 7 |
| Journal | Genetic Vaccines and Therapy |
| Volume | 9 |
| DOIs | |
| State | Published - Apr 6 2011 |
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ASJC Scopus subject areas
- Biotechnology
- Molecular Medicine
- Immunology
- Immunology and Allergy
Cite this
In-vitro model systems to study Hepatitis C Virus. / Ashfaq, Usman A.; Khan, Shaheen N.; Nawaz, Zafar; Riazuddin, Sheikh.
In: Genetic Vaccines and Therapy, Vol. 9, 7, 06.04.2011.Research output: Contribution to journal › Article
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TY - JOUR
T1 - In-vitro model systems to study Hepatitis C Virus
AU - Ashfaq, Usman A.
AU - Khan, Shaheen N.
AU - Nawaz, Zafar
AU - Riazuddin, Sheikh
PY - 2011/4/6
Y1 - 2011/4/6
N2 - Hepatitis C virus (HCV) is a major cause of chronic liver diseases including steatosis, cirrhosis and hepatocellular carcinoma. Currently, there is no vaccine available for prevention of HCV infection due to high degree of strain variation. The current treatment of care, Pegylated interferon α in combination with ribavirin is costly, has significant side effects and fails to cure about half of all infections. The development of in-vitro models such as HCV infection system, HCV sub-genomic replicon, HCV producing pseudoparticles (HCVpp) and infectious HCV virion provide an important tool to develop new antiviral drugs of different targets against HCV. These models also play an important role to study virus lifecycle such as virus entry, endocytosis, replication, release and HCV induced pathogenesis. This review summarizes the most important in-vitro models currently used to study future HCV research as well as drug design.
AB - Hepatitis C virus (HCV) is a major cause of chronic liver diseases including steatosis, cirrhosis and hepatocellular carcinoma. Currently, there is no vaccine available for prevention of HCV infection due to high degree of strain variation. The current treatment of care, Pegylated interferon α in combination with ribavirin is costly, has significant side effects and fails to cure about half of all infections. The development of in-vitro models such as HCV infection system, HCV sub-genomic replicon, HCV producing pseudoparticles (HCVpp) and infectious HCV virion provide an important tool to develop new antiviral drugs of different targets against HCV. These models also play an important role to study virus lifecycle such as virus entry, endocytosis, replication, release and HCV induced pathogenesis. This review summarizes the most important in-vitro models currently used to study future HCV research as well as drug design.
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UR - http://www.scopus.com/inward/citedby.url?scp=79953672428&partnerID=8YFLogxK
U2 - 10.1186/1479-0556-9-7
DO - 10.1186/1479-0556-9-7
M3 - Article
C2 - 21466709
AN - SCOPUS:79953672428
VL - 9
JO - Genetic Vaccines and Therapy
JF - Genetic Vaccines and Therapy
SN - 1479-0556
M1 - 7
ER -