In-vitro model systems to study Hepatitis C Virus

Usman A. Ashfaq, Shaheen N. Khan, Zafar Nawaz, Sheikh Riazuddin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Hepatitis C virus (HCV) is a major cause of chronic liver diseases including steatosis, cirrhosis and hepatocellular carcinoma. Currently, there is no vaccine available for prevention of HCV infection due to high degree of strain variation. The current treatment of care, Pegylated interferon α in combination with ribavirin is costly, has significant side effects and fails to cure about half of all infections. The development of in-vitro models such as HCV infection system, HCV sub-genomic replicon, HCV producing pseudoparticles (HCVpp) and infectious HCV virion provide an important tool to develop new antiviral drugs of different targets against HCV. These models also play an important role to study virus lifecycle such as virus entry, endocytosis, replication, release and HCV induced pathogenesis. This review summarizes the most important in-vitro models currently used to study future HCV research as well as drug design.

Original languageEnglish
Article number7
JournalGenetic Vaccines and Therapy
Volume9
DOIs
StatePublished - Apr 6 2011

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Hepacivirus
Virus Diseases
Hepatovirus
In Vitro Techniques
Virus Internalization
Replicon
Ribavirin
Drug Design
Endocytosis
Virion
Interferons
Antiviral Agents
Liver Diseases
Hepatocellular Carcinoma
Fibrosis
Chronic Disease
Research Design
Vaccines
Viruses
Infection

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Immunology
  • Immunology and Allergy

Cite this

In-vitro model systems to study Hepatitis C Virus. / Ashfaq, Usman A.; Khan, Shaheen N.; Nawaz, Zafar; Riazuddin, Sheikh.

In: Genetic Vaccines and Therapy, Vol. 9, 7, 06.04.2011.

Research output: Contribution to journalArticle

Ashfaq, Usman A. ; Khan, Shaheen N. ; Nawaz, Zafar ; Riazuddin, Sheikh. / In-vitro model systems to study Hepatitis C Virus. In: Genetic Vaccines and Therapy. 2011 ; Vol. 9.
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