In Vitro Model Systems for the Study of Hormone-Dependent Human Breast Cancer

Howard L. Bleich, Emily S. Boro, Marc E Lippman, C. Kent Osborne, Richard Knazek, Nathaniel Young

Research output: Contribution to journalReview article

78 Citations (Scopus)

Abstract

The hormone-dependent nature of some human breast cancers has been appreciated since the pioneering work of Beatson more than 75 years ago.1 Since then, a variety of ablative and additive therapies have been used to induce clinically important palliations in patients with metastatic breast cancer. Such tumor regressions have also been duplicated in several animal-model systems — notably, in rats with dimethylbenz(a)anthracene-induced mammary cancer.2 Nonetheless, the data accumulated in clinical and animal studies have failed to define the mechanisms whereby adrenalectomy, hypophysectomy or treatment with androgens, estrogens, progestins or glucocorticoids leads to tumor regression in some patients. In vivo studies.

Original languageEnglish (US)
Pages (from-to)154-159
Number of pages6
JournalNew England Journal of Medicine
Volume296
Issue number3
DOIs
StatePublished - Jan 20 1977
Externally publishedYes

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Hormones
Breast Neoplasms
Hypophysectomy
Adrenalectomy
Progestins
Glucocorticoids
Androgens
Neoplasms
Estrogens
Breast
Animal Models
Therapeutics
In Vitro Techniques
anthracene
Clinical Studies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bleich, H. L., Boro, E. S., Lippman, M. E., Osborne, C. K., Knazek, R., & Young, N. (1977). In Vitro Model Systems for the Study of Hormone-Dependent Human Breast Cancer. New England Journal of Medicine, 296(3), 154-159. https://doi.org/10.1056/NEJM197701202960307

In Vitro Model Systems for the Study of Hormone-Dependent Human Breast Cancer. / Bleich, Howard L.; Boro, Emily S.; Lippman, Marc E; Osborne, C. Kent; Knazek, Richard; Young, Nathaniel.

In: New England Journal of Medicine, Vol. 296, No. 3, 20.01.1977, p. 154-159.

Research output: Contribution to journalReview article

Bleich, HL, Boro, ES, Lippman, ME, Osborne, CK, Knazek, R & Young, N 1977, 'In Vitro Model Systems for the Study of Hormone-Dependent Human Breast Cancer', New England Journal of Medicine, vol. 296, no. 3, pp. 154-159. https://doi.org/10.1056/NEJM197701202960307
Bleich, Howard L. ; Boro, Emily S. ; Lippman, Marc E ; Osborne, C. Kent ; Knazek, Richard ; Young, Nathaniel. / In Vitro Model Systems for the Study of Hormone-Dependent Human Breast Cancer. In: New England Journal of Medicine. 1977 ; Vol. 296, No. 3. pp. 154-159.
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