In vitro methods to complement in vivo approaches utilizing combinations of chemotherapy and immunotherapy

M. M. Sigel, W. Lichter, Diana M Lopez

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cell cultures have already proven their worth in measuring the cytotoxic and cytostatic effects of many synthetic drugs as well as drugs derived from natural products. New methods available for the study of cytokinetics and cellular morphology should be added to the existing procedures for the evaluation of actions of single drugs and drug combinations applied at one time or in sequence. Lymphocyte functions amenable to measurements in vitro have provided useful criteria for the assessment of the immunologic status of animals and patients undergoing chemotherapy. Greater use should be made of in vitro methods employing lymphocytes. The blastogenic responses of lymphocytes as well as the cytotoxic functions of these cells should be exploited for measurement of drug action in vitro, thereby providing in vitro parallels for in vivo studies.

Original languageEnglish
Title of host publicationCANCER CHEMOTHER.REP.
Pages109-114
Number of pages6
Volume4
Edition1
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Medicine(all)

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