In vitro determination of relative corticosteroid potency

H. L. Cantrill, S. R. Waltman, Paul Palmberg, H. A. Zink, B. Becker

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The corticosteroid concentration required to inhibit phytohemagglutinin stimulated human lymphocyte transformation by 50% was determined for three corticosteroids. The relative potency of hydrocortisone, prednisolone and dexamethasone determined in 16 patients was 1.00, 2.43, and 24.7 respectively. This assay is proposed as an objective tool for comparison of relative corticosteroid potency in man.

Original languageEnglish
Pages (from-to)1073-1077
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume40
Issue number6
StatePublished - Dec 1 1975
Externally publishedYes

Fingerprint

Adrenal Cortex Hormones
Lymphocytes
Phytohemagglutinins
Lymphocyte Activation
Prednisolone
Dexamethasone
Hydrocortisone
Assays
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Cantrill, H. L., Waltman, S. R., Palmberg, P., Zink, H. A., & Becker, B. (1975). In vitro determination of relative corticosteroid potency. Journal of Clinical Endocrinology and Metabolism, 40(6), 1073-1077.

In vitro determination of relative corticosteroid potency. / Cantrill, H. L.; Waltman, S. R.; Palmberg, Paul; Zink, H. A.; Becker, B.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 40, No. 6, 01.12.1975, p. 1073-1077.

Research output: Contribution to journalArticle

Cantrill, HL, Waltman, SR, Palmberg, P, Zink, HA & Becker, B 1975, 'In vitro determination of relative corticosteroid potency', Journal of Clinical Endocrinology and Metabolism, vol. 40, no. 6, pp. 1073-1077.
Cantrill, H. L. ; Waltman, S. R. ; Palmberg, Paul ; Zink, H. A. ; Becker, B. / In vitro determination of relative corticosteroid potency. In: Journal of Clinical Endocrinology and Metabolism. 1975 ; Vol. 40, No. 6. pp. 1073-1077.
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