In vitro determination of relative corticosteroid potency

Herbert L. Cantrill, Stephen R. Waltman, Paul F. Palmberg, Harry A. Zink, Bernard Becker

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The corticosteroid concentration required to inhibit phytohemagglutinin stimulated human lymphocyte transformation by 50% was determined for three corticosteroids. The relative potency of hydrocortisone, prednisolone and dexamethasone determined in 16 patients was 1.00, 2.43, and 24.7 respectively. This assay is proposed as an objective tool for comparison of relative corticosteroid potency in man.

Original languageEnglish (US)
Pages (from-to)1073-1077
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume40
Issue number6
DOIs
StatePublished - Jan 1 1975
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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