The corticosteroid concentration required to inhibit phytohemagglutinin stimulated human lymphocyte transformation by 50% was determined for three corticosteroids. The relative potency of hydrocortisone, prednisolone and dexamethasone determined in 16 patients was 1.00, 2.43, and 24.7 respectively. This assay is proposed as an objective tool for comparison of relative corticosteroid potency in man.
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Clinical Biochemistry
- Biochemistry, medical